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Cancer

Autophagy and RAS signaling: Clinical implications

By Christina Towers, PhD

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Pancreatic Ductal Adenocarcinoma

Colorectal Cancer

CA19-9/Sialyl Lewis A

Christina Towers

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Breast cancer stem cells survive chemotherapy through S100A10-ANXA2-SPT6 interaction that epigenetically promotes OCT4-mediated stemness

Immunohistochemical staining of paraffin-embedded human breast carcinoma with rabbit polyclonal Oct4 antibody.

By Jamshed Arslan, Pharm D, PhD

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HIF-2 alpha/EPAS1

Deficiency of GluT1 leads to neurological problems while excess is involved in cancers

Immunohistochemical staining of formalin fixed paraffin embedded tissue of human placenta with rabbit polyclonal Glut1 antibody and staining developed using HRP-DAB with hematoxylin counterstaining.

By Jamshed Arslan, Pharm. D., PhD.

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GluT1-deficiency syndrome (GDS)

Hepatocellular Carcinoma

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Migrasomes: A Novel Vesicle Involved in Intercellular Signaling

By Christina Towers, PhD

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Autophagy Research Update: What a difference a year makes!

By Christina Towers, PhD

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Selective Autophagy

Christina Towers

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Autophagy and Metastasis

EpCAM/TROP1 is localized by immunohistochemical analysis of human breast carcinoma tissue to the cell membrane and intercellular spaces.

By Christina Towers, PhD

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Christina Towers

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Detecting HIF alpha and beyond: Best controls for hypoxia Western blot analysis

Analysis of HIF-1 alpha expression in whole cell lysates from HeLa cells in culture treated or untreated with cobalt chloride and independent antibody validation where two different antibodies to HIF-1 alpha were used for immunoprecipitation and detection.

By Rosa Moreno, PhD.

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Neurovascular signaling for repair enhances brain metastasis

High expression of GFAP (green) identifies astrocytes in rat cerebellum

By Jamshed Arslan, Pharm. D., PhD.

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Immunohistochemistry

rxr-alpha-nr2b1

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Glypican 3 as a biomarker for gastro-esophageal adenocarcinoma

Expression of CD81 was detected by immunofluorescence with a mouse monoclonal antibody followed by secondary antibody labeled with DyLight488 and Phalloidin 568 staining for actin visualization

By Jamshed Arslan, Pharm. D., PhD.

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Exosome Markers

Carcinoembryonic antigen

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The Ins and Outs of Survivin

Exosomes arise from the late endosomal compartment through inward budding of multivesicular bodies and may contain multiple proteins, lipids, DNA, RNAs and biomolecules of viruses/prions.

By Rachel M.A. Linger, Ph.D.

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Cancer Research

ednrb-endothelin-r-type-b

Rachel M.A. Linger

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