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Epigenetics

Epigenetics of Depression: How Can Psychological Stress Alter Your DNA?

Chromatin reader domains of DNMT-targeting protein, UHRF1, are responsible for cancerous DNA hypermethylation

Negative feedback regulation of EPAS1 gene in non-small cell lung cancer through DNA methyltransferases

Nickel induces migratory and invasive phenotype in human epithelial cells by epigenetically activating ZEB1

Epigenetic Control of Autophagy

Bad news for stomach cancer: BAMBI protein inhibits gastric carcinoma via TGF-beta/epithelial-mesenchymal transition signaling

Beyond Genes: Treating Memory Loss with Minimum Adverse Effects

Autophagy: Pro or Anti-tumorigenic? And the role of epigenetics in this debate

By Christina Towers, PhD

Epigenetic mechanisms: new insights on the regulation of autophagy

Autophagy more than a cytosolic event

Autophagy is a cellular process whereby cytosolic components are broken down and eliminated or recycled. As a homeostatic mechanism, basal autophagic activity eliminates excess or abnormal proteins and organelles1. As an induced process, autophagy may be triggered by various external challenges, such as decreased nutrient and energy resources, and oxidative stress1.

H4 - Monitoring global chromatin structure through histone modifications

Histones make up the main protein component of chromatin and are responsible for storing and organizing the genome in a compact yet accessible manner. In addition to storage, histones play an important role in the regulation of various cellular processes such as DNA replication, transcription, and mitosis by regulating the accessibility of DNA to various DNA-binding proteins. Simply put, chromatin exists in “open” and “closed” states.

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