AMPK

By Christina Towers, PhD.

Mammalian target of Rapamycin (mTOR) is a serine/threonine kinase that regulates cell growth, proliferation, motility and survival.

ChREBP (carbohydrate response element-binding protein) is a glucose responsive basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor that binds MLX and then carbohydrate response element /ChoRE for the induction of genes involved in glycolysis, de novo lipogenesis (DNL), and fatty acid desaturation. ChREBP’s target genes includes glucokinase (GCK), fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), pyruvate kinase/liver type pyruvate kinase (PK1/ PKLR), delta-9-desaturase (SCD/SCD1) etc.

Adiponectin (also called AdipoQ and Acrp30) is a circulating cytokine primarily expressed in adipose tissue. A complex protein with a number of physiological roles, adiponectin antibody experiments have revealed multiple forms of the protein in circulation, including trimers, multioligomers and cleavage fragments. We at Novus Biologicals stock an extensive range of adiponectin antibodies, as well as recombinant proteins and ELISA adiponectin antibody kits.