SREBP1 Products

Description

SREBP (Sterol Regulatory Element Binding Protein) 1 and 2 are transcription factors which participate in the control of cholesterol homeostasis. SREBP proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. SREBPs may also play some role in the apoptotic processes.

SREBP1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.

Bioinformatics

Entrez	20787 Mouse 6720 Human 78968 Rat
Uniprot	AAH57388 Human NP_001005291 Human NP_004167 Human P36956 Human Q9WTN3 Mouse
Product By Gene ID	6720
Alternate Names	BHLHD1 Class D basic helix-loop-helix protein 1 SREBP 1c SREBP-1 SREBP1bHLHd1SREBP-1c sterol regulatory element binding protein-1 sterol regulatory element binding transcription factor 1 sterol regulatory element-binding protein 1 Sterol regulatory element-binding transcription factor 1

Research Areas for SREBP1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cholesterol Metabolism
Chromatin Research
Diabetes Research
Lipid and Metabolism
Transcription Factors and Regulators

Related SREBP1 Blog Posts

Check out the latest blog posts on SREBP1.

SREBP: Gatekeeper of Cholesterol Homeostasis SREBP1 (sterol-regulatory-element-binding protein 2) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. It regulates sterol and cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g. ...    Read more.

Metabolic Syndrome: Symptoms and associated disease states By Jamshed Arslan, Pharm. D., PhD. What is metabolic syndrome?It was 1988 when, after decades of research, Dr. GM Reaven    of the Stanford University, CA, explained the relationship between four diseases:...    Read more.

SREBP2 - regulating cholesterol homeostasis and lipid metabolism Sterol regulatory element-binding proteins (SREBP) are important transcription factors regulating the synthesis and uptake of lipids including cholesterol. This essential role in lipid metabolism makes investigations into the functions SREBPs im...    Read more.

Read more SREBP1 related blogs.