Zyxin Antibody (2D1)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using H00007791-M02	Applications	Species
Mise N, Savai R, Yu H et al. Zyxin is a TGF-b/Smad3 target gene that regulates lung cancer cell motility via integrin alpha5b1. J Biol Chem. 2012-07-09 [PMID: 22778267]

Array H00007791-M02

• Zyxin Antibodies
• Zyxin Proteins