Zyxin Antibody (2C10-4A7)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: WB.

Showing Publications 1 - 7 of 7.

Publications using H00007791-M01	Applications	Species
Ming-Chung W, Helen Y, Yin-Quan C et al. Early committed polarization of intracellular tension in response to cell shape determines the osteogenic differentiation of mesenchymal stromal cells. Acta Biomater. 2022-11-01 [PMID: 36328121]
Yang C, Yanjie S, Yanan D et al. Defective VWF secretion due to expression of MYH9-RD E1841K mutant in endothelial cells disrupts hemostasis. Blood Adv. 2022-08-09 [PMID: 35764499]
Kiyoshima D, Tatsumi H, Hirata H et al. Tensile loads on tethered actin filaments induce accumulation of cell adhesion-associated proteins in vitro. Langmuir 2018-09-25 [PMID: 30204447]
Higashiguchi K, Morita N, Matsuda K. et al. Structural Colored Balloon Composed of Temperature-Responsive Polymers Showing LCST Behavior. Langmuir 2018-09-28 [PMID: 30203977]
Kenific CM, Stehbens SJ, Goldsmith J et al. NBR1 enables autophagy-dependent focal adhesion turnover. J Cell Biol 2016-02-22 [PMID: 26903539] (WB)	WB
Wang ZH, Zhao ZJ, Xu K et al. Hereditary protein S deficiency leads to ischemic stroke. Mol Med Rep 2015-09-01 [PMID: 25997409] (WB)	WB
Hirata H, Tatsumi H, Sokabe M. Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner. J Cell Sci;121(Pt 17):2795-804. 2008-09-01 [PMID: 18682496]

Array H00007791-M01

• Zyxin Antibodies
• Zyxin Proteins