XPC Antibody

Human XPC (Xeroderma pigmentosum group C) is a member of a family of proteins that has been shown to be involved in the repair of DNA via the nucleotide excision repair (NER) pathway. Specifically, XPC is believed to be a part of a heteromeric protein complex that is involved in the recognition of the DNA lesions during global genomic repair but not transcription-coupled repair. XPC may play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C (XPC); also known as xeroderma pigmentosum III (XP3). XPC is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 7 of 7.

Publications using NB100-58801	Applications	Species
van den Heuvel D, Rodríguez-Martínez M, van der Meer PJ et Al. STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair Cell 2024-11-11 [PMID: 39547229]
Y van der We, H Golan-Berm, TET Mevissen, K Apelt, R González-P, J Goedhart, EE Heilbrun, ACO Vertegaal, D van den He, JC Walter, S Adar, MS Luijsterbu The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II Nat Commun, 2020-04-30;11(1):2104. 2020-04-30 [PMID: 32355176]
Muenyi CS, Pinhas AR, Fan TW, Brock GN, Helm CW, States JC. Sodium arsenite hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses. Toxicol Sci;127(1):139-49. 2012-05-01 [PMID: 22331493] (WB, Human)	WB	Human
Rageul J, Fremin C, Ezan F et al. The knock-down of ERCC1 but not of XPF causes multinucleation. DNA Repair (Amst) 2011-09-01 [PMID: 21839691]
van der Weegen Y, Berman HG, Mevissen TET, Apelt K The sequential and cooperative action of CSB, CSA and UVSSA targets the TFIIH complex to DNA damage-stalled RNA polymerase II bioRxiv (WB, Human)	WB	Human
Lee D, Apelt K, Lee SO et al. ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination Nucleic acids research 2022-03-07 [PMID: 35253893] (WB, Human)	WB	Human
van der Weegen Y, Berman HG, Mevissen TET, Apelt K The sequential and cooperative action of CSB, CSA and UVSSA targets the TFIIH complex to DNA damage-stalled RNA polymerase II Nat Commun 2020-11-07 [PMID: 33159085]

Array NB100-58801

• XPC Antibodies
• XPC ELISA Kits
• XPC Proteins