Wnt-7b Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Wnt-7b is a 46 kDa, secreted glycosylated protein that belongs to the Wnt family. Wnt proteins can be lipid-modified and are ligands for members of the frizzled family of receptors, which mediates cell-cell communication during development. Human Wnt-7b is synthesized as a 349 amino acid (aa) precursor that contains a 318 aa mature region. The mature region contains 24 cysteines and three potential N-linked glycosylation sites. Mature human Wnt-7b shares 99% aa sequence identity with mature mouse and rat Wnt-7b. Wnt-7b also shares 80% aa sequence identity with Wnt-7a.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 6 applications: ICC, IHC, IHC-Fr, IHC-P, Immunohistochemistry, Western Blot.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using AF3460	Applications	Species
Martin Flores, N;Podpolny, M;McLeod, F;Workman, I;Crawford, K;Ivanov, D;Leonenko, G;Escott-Price, V;Salinas, PC; Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model eLife 2024-01-29 [PMID: 38285009] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Militi, S;Nibhani, R;Jalali, M;Pauklin, S; RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling Cell reports 2023-09-18 [PMID: 37725511] (ICC, Human)	ICC	Human
J Seong, J Frias-Alde, V Holzmann, H Kagawa, G Sestini, H Heidari Kh, Y Scholte Op, M Kip, SJ Pradhan, L Verwegen, J Vivié, L Li, A Alemany, J Korving, F Darmis, A van Oudena, D Ten Berge, N Geijsen, NC Rivron Epiblast inducers capture mouse trophectoderm stem cells in�vitro and pattern blastoids for implantation in utero Cell Stem Cell, 2022-07-07;29(7):1102-1118.e8. 2022-07-07 [PMID: 35803228] (Western Blot, Mouse)	Western Blot	Mouse
Z Zhang, Y Xu, C Zhao Fzd7/Wnt7b signaling contributes to stemness and chemoresistance in pancreatic cancer Cancer Medicine, 2021-05-02;10(10):3332-3345. 2021-05-02 [PMID: 33934523] (IHC, Western Blot, Human)	IHC, Western Blot	Human
Shuai Jiang, Qiwen Li, Yimin Liu, Huimin Zhang, Qianyu Wang, Yu Chen et al. Activation of WNT7b autocrine eases metastasis of colorectal cancer via epithelial to mesenchymal transition and predicts poor prognosis BMC Cancer 2021-12-01 [PMID: 33607955]
Z Wang, P Yin, Y Sun, L Na, J Gao, W Wang, C Zhao LGR4 maintains HGSOC cell epithelial phenotype and stem-like traits Gynecol Oncol, 2020-09-24;0(0):. 2020-09-24 [PMID: 32980127] (Western Blot, Human)	Western Blot	Human
JS Beeler, CB Marshall, PI Gonzalez-E, TM Shaver, GL Santos Gua, ST Lea, KN Johnson, H Jin, BJ Venters, ME Sanders, JA Pietenpol p73 regulates epidermal wound healing and induced keratinocyte programming PLoS ONE, 2019-06-19;14(6):e0218458. 2019-06-19 [PMID: 31216312] (Western Blot, Human, Mouse)	Western Blot	Human, Mouse
Thomas Volckaert, Tingting Yuan, Cho-Ming Chao, Harold Bell, Alina Sitaula, Luisa Szimmtenings et al. Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells Developmental Cell 2017-10-01 [PMID: 29017029]
M Vesel, J Rapp, D Feller, E Kiss, L Jaromi, M Meggyes, G Miskei, B Duga, G Smuk, T Laszlo, I Karner, JE Pongracz ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling Respir. Res, 2017-03-24;18(1):52. 2017-03-24 [PMID: 28340578] (IHC-Fr, Human)	IHC-Fr	Human
Bruce F Kimler WINGLESS (WNT) signaling is a progesterone target for rat uterine stromal cell proliferation J. Endocrinol., 2016-03-14;229(2):197-207. 2016-03-14 [PMID: 26975616] (IHC-P, Rat)	IHC-P	Rat
Donna R. Newman, W. Shane Sills, Katherine Hanrahan, Amanda Ziegler, Kathleen McGinnis Tidd, Elizabeth Cook et al. Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-beta and WNT7B in Human Lung Fibroblasts Journal of Histochemistry & Cytochemistry 2016-02-01 [PMID: 26538547]
Shiah S, Hsiao J, Chang W, Chen Y, Jin Y, Wong T, Huang J, Tsai S, Hsu Y, Chou S, Yen Y, Jiang S, Shieh Y, Chang I, Hsiao M, Chang J Downregulated miR329 and miR410 promote the proliferation and invasion of oral squamous cell carcinoma by targeting Wnt-7b. Cancer Res, 2014-10-28;74(24):7560-72. 2014-10-28 [PMID: 25351956] (IHC, Human)	IHC	Human
Dali Zheng, Keith F. Decker, Tianhua Zhou, Jianquan Chen, Zongtai Qi, Kathryn Jacobs et al. Role of WNT7B-induced Noncanonical Pathway in Advanced Prostate Cancer Molecular Cancer Research 2013-05-01 [PMID: 23386686]
Chigita S, Sugiura T, Abe M, Kobayashi Y, Shimoda M, Onoda M, Shirasuna K CD82 inhibits canonical Wnt signalling by controlling the cellular distribution of beta-catenin in carcinoma cells. Int J Oncol, 2012-10-17;41(6):2021-8. 2012-10-17 [PMID: 23076981] (Western Blot, Human)	Western Blot	Human
Volckaert T, Dill E, Campbell A, Tiozzo C, Majka S, Bellusci S, De Langhe SP Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury. J. Clin. Invest., 2011-10-10;121(11):4409-19. 2011-10-10 [PMID: 21985786] (IHC-P, Mouse)	IHC-P	Mouse
Gogolla N, Galimberti I, Deguchi Y, Caroni P Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus. Neuron, 2009-05-28;62(4):510-25. 2009-05-28 [PMID: 19477153] (IHC-Fr, Western Blot, Mouse)	IHC-Fr, Western Blot	Mouse
Show All 16 Publications. Collapse Publications.

Array AF3460

• Wnt-7b Antibodies
• Wnt-7b ELISA Kits
• Wnt-7b Lysate