WDR5 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

WDR5 (WD repeat-containing protein 5; also BMP2-induced 3 kb gene protein/BIG3) is a nuclear, 36‑40 kDa monomeric member of the WD family of repeat proteins. It is known to be expressed in osteoblasts, osteocytes and chrondrocytes, among other cells, and appears to serve as a structural organizer for the histone methyltransferase MLL1 complex. This complex methylates histone H3, and within this complex, WDR5 binds to mono- or dimethylated histone H3 and serves as an anchor for complex subunits RbBP5, Ash2L and MLL1. Human WDR5 is 334 amino acids (aa) in length. It contains seven WD domains (aa 43‑333) that likely participate in protein-protein interactions, plus a phosphorylation site at Ser267. There are three isoform variants for WDR5. Human and mouse WDR5 are absolutely identical in aa sequence.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ChIP, IHC, Western Blot.

Showing Publications 1 - 7 of 7.

Publications using AF5810	Applications	Species
Zheng Li, Nan Liang, Na Wang, Yan Jia, Cui Tian WDR5 is a prognostic biomarker of brain metastasis from non-small cell lung cancer Frontiers in Oncology 2022-09-29 [PMID: 36249032]
Mengjie Ma, Jiafeng Zhou, Zhihua Ma, Hanxue Chen, Liang Li, Lin Hou et al. The Ash2l SDI Domain Is Required to Maintain the Stability and Binding of DPY30 Cells 2022-04-25 [PMID: 35563756]
Q Li, F Mao, B Zhou, Y Huang, Z Zou, AD denDekker, J Xu, S Hou, J Liu, Y Dou, RC Rao p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells Cell Rep, 2020-01-14;30(2):465-480.e6. 2020-01-14 [PMID: 31940490] (Western Blot, Mouse)	Western Blot	Mouse
W Xu, L Wang, Y An, J Ye Expression of WD Repeat Domain 5 (WDR5) is Associated with Progression and Reduced Prognosis in Papillary Thyroid Carcinoma Med. Sci. Monit., 2019-05-20;25(0):3762-3770. 2019-05-20 [PMID: 31107859] (IHC, Human)	IHC	Human
X Tan, S Chen, J Wu, J Lin, C Pan, X Ying, Z Pan, L Qiu, R Liu, R Geng, W Huang PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407 Cell Death Dis, 2017-03-16;8(3):e2686. 2017-03-16 [PMID: 28300833] (ChIP, IHC, Western Blot, Human)	ChIP, IHC, Western Blot	Human
Hopkin , Amelia S, Gordon , William, Klein , Rachel H, Espitia , Francisc, Daily , Kenneth, Zeller , Michael, Baldi , Pierre, Andersen , Bogi GRHL3/GET1 and trithorax group members collaborate to activate the epidermal progenitor differentiation program. PLoS Genet, 2012-07-19;8(7):e1002829. 2012-07-19 [PMID: 22829784] (IHC, Human)	IHC	Human
Liu L, Yin Y, Li Y Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis. Cell Res., 2012-03-27;22(8):1258-69. 2012-03-27 [PMID: 22453236] (Western Blot, Mouse)	Western Blot	Mouse

Array AF5810

• WDR5 Antibodies
• WDR5 Lysates
• WDR5 Proteins