VEGFR3/Flt-4 Antibody Pair [HRP] Summary
Description |
Solid Phase sandwich ELISA for the quantitative determination of Human VEGFR3/Flt-4. |
Specificity |
This solid phase sandwich ELISA utilizes a monoclonal antibody specific for Human VEGFR3/Flt-4. |
Standard Curve Range |
78.13-5000 pg/ml (example only; lot dependent) |
Sensitivity |
156.1 pg/ml (example only; lot dependent) |
Assay Type |
Sandwich ELISA |
Sample Volume |
100 ul |
Gene |
FLT4 |
Applications/Dilutions
Packaging, Storage & Formulations
Storage |
Storage of components varies. See protocol for specific instructions. |
Kit Components
Components
|
- Mouse Monoclonal Capture Antibody
- Mouse Monoclonal Detection Antibody (HRP-conjugated)
- Standard
|
Alternate Names for VEGFR3/Flt-4 Antibody Pair [HRP]
Background
FLT4, a VEGF Receptor type protein kinase, is an endothelial cell-specific receptor. Binding of the extracellular domain of FLT4 to the vascular endothelial growth factor-related protein VEGF-C stimulates tyrosine phosphorylation and mitogenesis of endothelial cells. FLT4 (-/-) mice have been shown to have defective blood vessel development in early embryos and to experience cardiovascular failure at embryonic day 9.5. A mutation in the FLT4 gene has been implicated in human hereditary lymphedema type I. Similarly, a mutation in the conserved catalytic domain of FLT4, in close proximity to the FLT4 mutations in human primary lymphedema, has been linked to the Chy mouse mutant.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are
guaranteed for 6 months from date of receipt.
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