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VDR/NR1I1/Vitamin D Receptor Antibody (H4537) [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IP, ELISA
Clone
H4537
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Suitable Sample Type
23015

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VDR/NR1I1/Vitamin D Receptor Antibody (H4537) [Unconjugated] Summary

Immunogen
Recombinant human VDR/NR1I1
aa 91-210
Specificity
This antibody specifically recognizes human VDR and cross reacts with mouse and rat VDR. Not yet tested in other species.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
VDR
Purity Statement
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunoprecipitation
  • Direct ELISA
Publications
Read Publications using
PP-H4537-00 in the following applications:

Packaging, Storage & Formulations

Storage
This antibody is stable for greater than six months when held at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Buffer
A liquid formulation in physiologic saline with 0.1% NaN3.
Preservative
0.1% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for VDR/NR1I1/Vitamin D Receptor Antibody (H4537) [Unconjugated]

  • NR1I1
  • NR1I1Nuclear receptor subfamily 1 group I member 11,25-dihydroxyvitamin D3 receptor
  • VDR
  • vitamin D1,25- dihydroxyvitamin D3 receptor
  • vitamin D3 receptor

Background

Vitamin D Receptor (VDR; NR1I1) is a member of the Steroid Receptor family related to the Pregnane X Receptor (PXR) and Constitutive Androstane Receptors (CARs). The natural ligand of VDR is 1, 25 di-hydroxyvitamin D3. VDR is expressed in osteoblasts, osteocytes, osteoclasts, bone, bone marrow, thymus and small intestine. VDR plays critical roles in calcium homeostasis, bone development and mineralization, as well as control of cell growth and differentiation. Retnoid X Receptors (RXRs) are the major partners for VDR since by heterodimerizing with VDR, they increase their DNA-binding affinity and select the correct spacing of direct repeat elements.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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VDR/NR1I1/Vitamin
D Receptor Antibody ( ...
PP-H4537-00
VDR/NR1I1/Vitamin D Receptor Antibody (H4537) [Unconjugated]
Species: Hu
Applications: WB, IHC, IP, ELISA

Publications for VDR/NR1I1/Vitamin D Receptor Antibody (PP-H4537-00)(2)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Western Blot.


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Bioinformatics

Gene Symbol VDR