UNC5H1/Unc5a Antibody [Unconjugated]

This product or the use of this product is covered by U.S. Patents owned by The Regents of the University of California. This product is for research use only and is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited. In order to obtain a license to use this product for such purposes, contact The Regents of the University of California.

U.S. Patent # 5,939,271, 6,277,585, and other U.S. and international patents pending.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Caenorhabditis elegans UNC5 (UNC = behaviorally uncoordinated) and its mammalian homologues, UNC5H1-4, UNC5A-D, and rostral cerebellar malformation (RCM), are transmembrane proteins belonging to the immunoglobulin (Ig) superfamily. All UNC5 family members have two Ig and two thrombospondin type 1 domains in their extracellular regions, as well as a conserved ZU-5 domain, a DCC (Deleted in Colorectal Cancer)-binding domain (DB) and a C-terminal death domain (DD) in their cytoplasmic regions (1, 2). Rat UNC5H1 cDNA encodes a 898 amino acid (aa) residues type I membrane protein with a putative 25 aa signal peptide and 332 aa extracellular domain. The extracellular domain of rat UNC5H1 shares approximately 98% and 65% amino acid sequence identity with mouse UNC5H1and rat UNC5H2, respectively.

UNC5 family proteins are receptors for the netrin/UNC6 family of secreted axon guidance cues that are laminin-related proteins. Netrin family proteins can act as a chemoattractant for some axons and as a chemorepellent for others. Besides UNC5, netrin family proteins also bind to the DCC family of type I transmembrane receptors and to adenosine A2b receptor, a G protein-coupled seven-transmembrane receptor belonging to the adenosine receptor family (3, 4). In vitro, netrin binding to DCC family receptors in the absence of UNC5 is associated with axon attraction. However, the DCC-mediated attraction to netrin is converted to repulsion by binding of UNC5 to the DCC-netrin complex. In vivo, the mechanisms of netrin-dependent axon attraction and repulsion are more complex and may include UNC5‑mediated repulsion that is independent of DCC (1, 5). Besides their roles in axon guidance and neuronal migration, the UNC5 and DCC families also act as dependence receptors and exert pro-apoptotic effects in the absence of netrin (6).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC-Fr.

Showing Publications 1 - 3 of 3.

Publications using AF1405	Applications	Species
Victor H. Guaiquil, Cissy Xiao, Daniel Lara, Greigory Dimailig, Qiang Zhou Expression of axon guidance ligands and their receptors in the cornea and trigeminal ganglia and their recovery after corneal epithelium injury Experimental Eye Research 2022-06-01 [PMID: 35427568]
Rieko Muramatsu, Soichiro Nakahara, Junya Ichikawa, Keisuke Watanabe, Norio Matsuki, Ryuta Koyama The ratio of ‘deleted in colorectal cancer’ to ’uncoordinated-5A‘ netrin-1 receptors on the growth cone regulates mossy fibre directionality Brain 2010-01-01 [PMID: 19858080]
Hoang S, Liauw J, Choi M Netrin-4 enhances angiogenesis and neurologic outcome after cerebral ischemia. J. Cereb. Blood Flow Metab., 2008-11-05;29(2):385-97. 2008-11-05 [PMID: 18985053] (IHC-Fr, Mouse)	IHC-Fr	Mouse

Array AF1405

• UNC5H1/Unc5a Antibodies
• UNC5H1/Unc5a Lysate
• UNC5H1/Unc5a Proteins and Enzymes