Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7661) - Azide and BSA Free Summary
Description |
Antibody without azide - store at -20 to -80C. Non-hazardous. No MSDS required. |
Immunogen |
Recombinant full-length human Tryptophan Hydroxylase 1/TPH-1 protein |
Localization |
Cytoplasm, Nucleus |
Isotype |
IgG2 Kappa |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
TPH1 |
Purity |
Protein A or G purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry-Paraffin 1-2ug/ml for 30 minutes at RT
|
Application Notes |
Immunohistochemistry-Paraffin 1-2ug/ml for 30 minutes at RT. Optimal dilution for a specific application should be determined.. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes |
Packaging, Storage & Formulations
Storage |
Store at -20 to -80C. Avoid freeze-thaw cycles. |
Buffer |
10mM PBS |
Preservative |
No Preservative |
Concentration |
1 mg/ml |
Purity |
Protein A or G purified |
Alternate Names for Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7661) - Azide and BSA Free
Background
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and might be related to the pathogenesis of major depression (MD). Two isoforms are known, TPH1 and TPH2. (1). TPH1 is phosphorylated by cAMP-dependent protein kinase A (2). Recently, it has been shown that expression of the TPH1 gene is increased in lungs and pulmonary endothelial cells from patients with idiopathic pulmonary arterial hypertension. Results indicate that TPH1 and peripheral serotonin play an essential role in the development of hypoxia-induced elevations in pulmonary pressures and hypoxia-induced pulmonary vascular remodeling. In addition, the results suggest that, in mice, serotonin has differential effects on the pulmonary vasculature and right ventricular hypertrophy (3).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for Tryptophan Hydroxylase 1/TPH-1 Antibody (NBP3-27018) (0)
Secondary Antibodies
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