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TrkA Antibody (RM423)

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Western Blot: TrkA Antibody (RM423) [NBP3-09176] - Western Blot of mouse brain tissue lysate using NBP3-09176 at a 1:2000 dilution.
Western Blot: TrkA Antibody (RM423) [NBP3-09176] - Western Blot of mouse brain tissue lysate using NBP3-09176 at a 1:2000 dilution.
Immunohistochemistry-Paraffin: TrkA Antibody (RM423) [NBP3-09176] - Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using NBP3-09176 at a 1:100 dilution.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC
Clone
RM423
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

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TrkA Antibody (RM423) Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
A peptide corresponding to the C-terminus of human TrkA
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
NTRK1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:100 - 1:200
  • Immunohistochemistry-Paraffin
  • Western Blot 1:1000 - 1:2000

Reactivity Notes

This antibody may also react to mouse or rat TrkA, as predicted by immunogen homology

Packaging, Storage & Formulations

Storage
Store at -20C.
Buffer
50% Glycerol/PBS, 1% BSA
Preservative
0.09% Sodium Azide
Purity
Protein A purified

Alternate Names for TrkA Antibody (RM423)

  • DKFZp781I14186
  • EC 2.7.10
  • EC 2.7.10.1
  • MTChigh affinity nerve growth factor receptor
  • Neurotrophic tyrosine kinase receptor type 1
  • neurotrophic tyrosine kinase, receptor, type 1
  • NTRK1
  • NTRK-1
  • p140-TrkA
  • TRK1-transforming tyrosine kinase protein
  • TrkA
  • Trk-A
  • TRKAOncogene TRK
  • TRKTRK1
  • tyrosine kinase receptor A

Background

The Trk proto-oncogene encodes a 140 kDa, membrane-spanning protein tyrosine kinase that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that Trk A binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of Trk A as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF (1). Trk A was found to be expressed in the nervous system and phosphorylated in response to NGF (Nerve Growth Factor). Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes (2). Trk A is expressed in neural and nonneuronal tissues. Like RET, Trk A is often activated by rearrangements that involve one of at least five other genes in papillary thyroid carcinoma (PTC) (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TrkA Antibody
(RM423)
NBP3-09176
TrkA Antibody (RM423)
Species: Hu, Mu, Rt
Applications: WB, IHC

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Product General Protocols

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FAQs for TrkA Antibody (NBP3-09176). (Showing 1 - 1 of 1 FAQ).

  1. I am searching (with difficulty) for an antibody against Trka which can be used in flow cytometry. Since I am planning to use it for bead sorting of live cells it needs to be for a part of the receptor which is on the outside of the cell. Please can you let me know if you can help me with this.
    • NBP1-47436, NB100-98815 and NB100-65266 all bind to the extracellular domain of Trka, however, none of them are guaranteed for use in flow cytometry. Our only flow cytometry guaranteed antibodies bind to the intracellular domain. This does not mean one of these antibodies won't work for flow, we just can not guarantee it. If you would be interested in testing this novel application on one of our Trka antibodies, please take a look at our Innovators Reward Program.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol NTRK1