TRF-1 Products

Description

Telomeric repeat binding factor 1 (TRF1, TERF1, PIN2, TRBF1) and telomeric repeat binding factor 2 (TRF2, TERF2, TRBF2) are present at telomeres throughout the cell cycle, where they regulate telomerase by acting in cis to limit the elongation of individual chromosome ends. Telomerase adds hexameric repeats of TTAGGG to the ends of chromosomal DNA. This telomerase enzyme plays an influential role in cellular immortalization and cellular senescence. TRF1 negatively regulates telomere elongation, while TRF2 protects the chromosome ends by inhibiting end-to-end fusions. Downregulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression. TRF1 has an acidic N-terminus while TRF2 has a basic N-terminus. TRF2 localizes in the nucleolus at G0 and S and diffuses out of the nucleolus in G2 phase. During mitosis TRF2 disperses from the condensed chromosomes and returns to the nucleolus at cytokinesis.

Bioinformatics

Entrez	21749 Mouse 297758 Rat 7013 Human
Uniprot	NM_003218 Human NP_003209 Human NP_059523 Human P54274 Human
Product By Gene ID	7013
Alternate Names	NIMA-interacting protein 2 PIN2hTRF1-AS Telomeric protein Pin2/TRF1 telomeric repeat binding factor (NIMA-interacting) 1 telomeric repeat binding factor 1 telomeric repeat binding protein 1 telomeric repeat-binding factor 1 TERF1 TRBF1 TRF1FLJ41416 TRFt-TRF1 TTAGGG repeat-binding factor 1

Research Areas for TRF-1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Cell Cycle and Replication
Cellular Markers
Chromatin Research
Core ESC-Like Genes
Stem Cell Markers