TRAP220/MED1 Antibody

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ChIP, IF/IHC, KD.

Showing Publications 1 - 3 of 3.

Publications using NB100-2574	Applications	Species
Edwin RK, Acharya LP, Maity SK et al. TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice Biochimica et biophysica acta. Molecular basis of disease 2023-09-24 [PMID: 37751782] (ChIP, Mouse)	ChIP	Mouse
Kurosaki T, Mitsutomi S, Hewko A et al. Integrative omics indicate FMRP sequesters mRNA from translation and deadenylation in human neuronal cells Molecular cell 2022-11-01 [PMID: 36356584]
BrUckmann NH, Bennedsen SN, Duijf PHG et al. A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence Cell Death Dis 2019-11-06 [PMID: 31695025] (KD, IF/IHC, Human)	KD, IF/IHC	Human

Array NB100-2574

• TRAP220/MED1 Antibodies
• TRAP220/MED1 Proteins