TRAF-5 Antibody (55A219) Summary
Immunogen |
Anti-TRAF5 monoclonal antibody was raised against a fusion protein corresponding to amino acids 77 to 186 of human TRAF5. |
Localization |
Cytoplasmic (probable) |
Isotype |
IgG |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
TRAF5 |
Purity |
Protein G purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
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Application Notes |
A 66 kDa band is seen in Western Blot (predicted molecular weight 66.8 kDa). |
Control |
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Reactivity Notes
Not yet tested in other species.
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
PBS containing 0.05% BSA |
Preservative |
0.05% Sodium Azide |
Concentration |
0.5 mg/ml |
Purity |
Protein G purified |
Alternate Names for TRAF-5 Antibody (55A219)
Background
Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor . Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymhocyte activation.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Product General Protocols
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Video Protocols
FAQs for TRAF-5 Antibody (NB600-1107). (Showing 1 - 1 of 1 FAQ).
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Are the following monoclonals purified from ascites or from tissue culture supernatant? NB100-56541, NB100-56705, NB600-1298, NB100-56534, NB100-56505, NBP2-24873, NB600-1107, NBP2-24917, NB100-56524, NB100-56712
- These antibodies are all purified from tissue culture supernatant.
Control Lysate(s)
Secondary Antibodies
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Isotype Controls
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