TOR/mTOR Antibody

FKBP 12 rapamycin associated protein (FRAP) is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 235 kDa protein (symbolized RAFT 1) with significant homology to the Saccharomyces cerevisiae protein TOR 1 and has been shown to associate with the immunophilin FKBP 12 in a rapamycin-dependent fashion. The FKBP 12 rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP 12 rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, IF/IHC, WB.

Showing Publications 1 - 9 of 9.

Publications using NB100-240	Applications	Species
Sikora M, ?mieszek A, Pielok A, Marycz K MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM/P6 mice Stem cell research & therapy 2023-03-29 [PMID: 36978118] (ICC/IF, Mouse) Details: Dilution used in ICC/IF 1:1000	ICC/IF	Mouse
Xie B, Zhao M, Song D et Al. Induction of autophagy and suppression of type I IFN secretion by CSFV Autophagy 2020-03-21 [PMID: 32160078]
Puigoriol-Illamola D, Martinez-Damas M, Grinan-Ferre C, Pallas M Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice Preprints 2020-01-29 [PMID: 32050516] (WB, Mouse)	WB	Mouse
Lisi L, Ciotti GMP, Chiavari M et al. Phospho-mTOR expression in human glioblastoma microglia-macrophage cells Neurochem. Int. 2019-06-10 [PMID: 31195027] (WB, Human)	WB	Human
Guo Y, Wang F, Li H et al. Metformin Protects Against Spinal Cord Injury by Regulating Autophagy via the mTOR Signaling Pathway. Neurochem Res 2018-05-04 [PMID: 29728793] (Rat)		Rat
Suzuki H, Roa JC, Kawamoto T et al. Expression of insulin-like growth factor I receptor as a biomarker for predicting prognosis in biliary tract cancer patients. Mol Clin Oncol 2015-05-01 [PMID: 26137252] (IF/IHC)	IF/IHC
Liu DC, Yang ZL. MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma. Diagn Cytopathol. 2011-09-30 [PMID: 21964981] (IF/IHC, Human)	IF/IHC	Human
Lionello M, Blandamura S, Loreggian L, Ottaviano G, Giacomelli L, Marchese-Ragona R, Velardita C, Staffieri A, Marioni G. High mTOR expression is associated with a worse oncological outcome in laryngeal carcinoma treated with postoperative radiotherapy: a pilot study. J Oral Pathol Med;41(2):136-40. doi: 10.1111/j.1600-0714.2011.01083.x. 2012-02-01 [PMID: 21943204]
Bolster DR, Vary TC, Kimball SR et al. Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation. J Nutr 2004-07-01 [PMID: 15226457]

Array NB100-240

• TOR/mTOR Antibodies
• TOR/mTOR ELISA Kit
• TOR/mTOR Lysate
• TOR/mTOR Proteins