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Thyroglobulin Antibody (SPM517) [Biotin]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications Flow, IHC, CyTOF-ready
Clone
SPM517
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-34777AF350
Alexa Fluor 405
NBP2-34777AF405
Alexa Fluor 488
NBP2-34777AF488
Alexa Fluor 532
NBP2-34777AF532
Alexa Fluor 594
NBP2-34777AF594
Alexa Fluor 647
NBP2-34777AF647
Alexa Fluor 700
NBP2-34777AF700
Alexa Fluor 750
NBP2-34777AF750
Allophycocyanin
NBP2-34777APC
CoraFluor 1
NBP2-34777CL1
DyLight 350
NBP2-34777UV
DyLight 405
NBP2-34777V
DyLight 488
NBP2-34777G
DyLight 550
NBP2-34777R
DyLight 594
NBP2-34777DL594
DyLight 650
NBP2-34777C
DyLight 680
NBP2-34777FR
DyLight 755
NBP2-34777IR
FITC
NBP2-34777F
HRP
NBP2-34777H
Janelia Fluor 525
NBP2-34777JF525
Janelia Fluor 549
NBP2-34777JF549
Janelia Fluor 585
NBP2-34777JF585
Janelia Fluor 635
NBP2-34777JF635
Janelia Fluor 646
NBP2-34777JF646
Janelia Fluor 669
NBP2-34777JF669
PE
NBP2-34777PE
PerCP
NBP2-34777PCP
Unconjugated
NBP2-32997-0.1mg
mFluor Violet 450 SE
NBP2-34777MFV450
mFluor Violet 500 SE
NBP2-34777MFV500
mFluor Violet 610 SE
NBP2-34777MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-32997-0.1mg
IHC-Prediluted
NBP2-45120
Azide and BSA Free
NBP2-34777-0.1mg
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Thyroglobulin Antibody (SPM517) [Biotin] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Human thyroid follicular cells
Localization
Cytoplasmic, Secreted
Marker
Thyroidal Cell Marker
Specificity
Thyroglobulin is a 660kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TG
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Readout System

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for Thyroglobulin Antibody (SPM517) [Biotin]

  • AITD3
  • AITD3TGN
  • cog
  • TDH3
  • Tg
  • TGN
  • Thyroglobulin

Background

Thyroglobulin is synthesized by the follicular epithelial cells of the thyroid. Thyroglobulin is the glycoprotein precursor to the thyroid hormones. Its synthesis and metabolism have seemingly wasteful features. It has a molecular weight of 660,000, with 2 identical subunits of MW 300,000 and 10% sugars; yet its complete hydrolysis yields only 2 to 4 molecules of the iodothyroxines T4 and T3. Baas et al. (1986) showed that the TG gene encodes an 8.7-kb mRNA, covers at least 300 kb of genomic DNA and contains at least 37 exons separated by introns as large as 64 kb. A striking structural difference between the 5-prime and 3-prime parts of the gene suggested that it is composed of 2 evolutionarily different regions. The first 30 kb of DNA encodes 3 kb of the mRNA yielding an exon:intron ratio of 1:10, whereas the remaining 270 kb encodes 5.7 kb of the mRNA with a ratio of 1.47.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Thrombopoietin/THPO [U
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C-Reactive
Protein/CRP [Biotin]
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Procalcitonin Antibody (44D9)
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M6000B
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Species: Mu
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Secondary Antibodies

 

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TTF1 / NKX2.1 - An essential regulator of lung development with implications in cancer diagnostics
Thyroid transcription factor 1 (TTF-1), also known as NKX2.1, is a conserved master regulatory transcription factor involved in the development of the lung, brain, and thyroid (1). In the lung TTF-1 positively regulates the expression of several lu...  Read full blog post.
mFluor Violet Conjugated Antibodies

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Bioinformatics

Gene Symbol TG