Species: Hu, Mu, Rt
Applications: Flow, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Thyroglobulin is synthesized by the follicular epithelial cells of the thyroid. Thyroglobulin is the glycoprotein precursor to the thyroid hormones. Its synthesis and metabolism have seemingly wasteful features. It has a molecular weight of 660,000, with 2 identical subunits of MW 300,000 and 10% sugars; yet its complete hydrolysis yields only 2 to 4 molecules of the iodothyroxines T4 and T3. Baas et al. (1986) showed that the TG gene encodes an 8.7-kb mRNA, covers at least 300 kb of genomic DNA and contains at least 37 exons separated by introns as large as 64 kb. A striking structural difference between the 5-prime and 3-prime parts of the gene suggested that it is composed of 2 evolutionarily different regions. The first 30 kb of DNA encodes 3 kb of the mRNA yielding an exon:intron ratio of 1:10, whereas the remaining 270 kb encodes 5.7 kb of the mRNA with a ratio of 1.47.
Bioinformatics
Entrez |
Mouse Rat Human |
Uniprot |
Human Human |
Product By Gene ID |
7038 |
Alternate Names |
- AITD3TGN
- TDH3
- Tg
- thyroglobulin
|
Research Areas for Thyroglobulin
Find related products by research area and learn more about each of the different research areas below.
CancerCell Biology