Thioredoxin Reductase 1/TRXR1 Antibody (489804)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Thioredoxin reductase 1 (TRXR1) is an approximately 70 kDa member of the class-I pyridine nucleotide-disulfide oxidoreductase family.  Human TRXR1 is 649 amino acids (aa) in length. Residues 151-152 constitute a propeptide that is deleted from the mature protein. Splicing variants produce five additional isoforms for human TRXR1. Isoform 2 has a 32 aa substitution for aa 107-138 and a deletion of aa 1-106. Isoform 3 has a deletion of aa 1-51 and a 49 aa substitution for aa 52-100. Isoform 4 is missing aa 1-98 and has a 3 aa substitution for aa 99-101. Isoform 5 has a deletion of aa 1-150. Residues 56-156 make up a glutaredoxin domain, and residues 520-632 constitute a pyridine nucleotide-disulphide oxidoreductase dimerization domain. In addition, there are three phosphotyrosines at positions 161, 163, and 281, and a selenocysteine at position 648. Human TRXR1 shares 74% and 70% aa sequence identity with mouse and rat TRXR1, respectively. Isoform 1 is involved in glutaredoxin activity as well as thioredoxin reductase activity, and it induces actin and tubulin polymerization, which leads to formation of cell membrane protrusions.  Isoform 4 has been shown to enhance the transcriptional activity of the beta receptor only. Finally, isoform 5 mediates cell death induced by a combination of interferon-beta and retinoic acid. Isoform 1 is expressed mostly in the Leydig cells, but also in the ovary, spleen, heart, liver, kidney, and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in the kidney, uterus, testis, ovary, prostate, placenta, and fetal liver.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 5 of 5.

Publications using MAB7428	Applications	Species
Sicong Wang, Erin Clapper, Kathryn F. Tonissen, Giovanna Di Trapani Co-Targeting of BTK and TrxR as a Therapeutic Approach to the Treatment of Lymphoma Antioxidants (Basel) 2023-02-20 [PMID: 36830087]
Sara Evke, Qishan Lin, Juan Andres Melendez, Thomas John Begley Epitranscriptomic Reprogramming Is Required to Prevent Stress and Damage from Acetaminophen Genes (Basel) 2022-02-25 [PMID: 35327975]
Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins et al. The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene Epigenetics 2020-10-02 [PMID: 32303148]
Iart Luca Shytaj, Bojana Lucic, Mattia Forcato, Carlotta Penzo, James Billingsley, Vibor Laketa et al. Alterations of redox and iron metabolism accompany the development of HIV latency The EMBO Journal 2020-05-04 [PMID: 32157726]
Y Fan, M Makar, MX Wang, HW Ai Monitoring thioredoxin redox with a genetically encoded red fluorescent biosensor Nat. Chem. Biol., 2017-06-26;0(0):. 2017-06-26 [PMID: 28671680] (Western Blot, Human)	Western Blot	Human

Array MAB7428

• Thioredoxin Reductase 1/TRXR1 Antibodies
• Thioredoxin Reductase 1/TRXR1 ELISA Kits
• Thioredoxin Reductase 1/TRXR1 Proteins