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TfR2 Antibody

Images

 
Immunohistochemistry-Paraffin: TfR2 Antibody [NBP3-17003] - Staining of human duodenum shows low expression as expected.
Immunohistochemistry-Paraffin: TfR2 Antibody [NBP3-17003] - Analysis in human liver and duodenum tissues using Anti-TFR2 antibody. Corresponding TFR2 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: TfR2 Antibody [NBP3-17003] - Staining of human liver shows high expression.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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TfR2 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: SVLVVSEDVNYEPDLDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALTQDIRAALSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYS
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TFR2
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Reactivity Notes

Mouse, Rat (80%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.2, 40% glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for TfR2 Antibody

  • HFE3
  • HFE3transferrin receptor protein 2
  • MGC126368
  • TfR2
  • TFRC2
  • transferrin receptor 2

Background

TFR2 is a gene that codes for a protein with three isoforms, with lengths of 801, 630, and 774 amino acids and weights of approximately 89, 70, and 86 kDa respectively. TFR2 helps in the cellular uptake of transferrin-bound iron as well as iron metabolism, erythrocyte differentiation, and hepatocyte function. Current studies are being done on several diseases and disorders related to this gene including porphyria cutanea tarda, iron overload, beta thalassemia, liver cirrhosis, hepatitis C, fatty liver disease, leukemia, lymphoma, liver disease, and cystic fibrosis. TRF2 has also been shown to have interactions with HFE, TF, UBC, and SOCS3 in pathways such as the AMPK enzyme complex and iron metabolism in the placenta pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TFR2