TFCP2L1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TFCP2L1 (Transcription factor CP2‑like protein # 1; also LBP‑9) is a 54 kDa (predicted) member of the CP2 subfamily, grh/CP2 family of proteins. It is expressed in placental synctiotrophoblast cells, and regulates the production of CYP11A1/P450scc. P450scc is a cholesterol cleavage enzyme that generates pregnenolone, a necessary intermediate in the formation of progesterone. TFCP2L1 both positively and negatively regulates P450scc synthesis through homodimerization and heterodimerization with LBP‑1b. Human TFCP2L1 is 479 amino acids (aa) in length. It contains a transcriptional repressor region (aa 100‑200) and a dimerization domain (aa 300‑479). There is one splice variant that shows a deletion of aa 400‑464. Human TFCP2L1 is 73% aa identical to human TFCP2, and 93% aa identical to mouse CRTR‑1, a closely related molecule that may not represent the actual mouse ortholog to TFCP2L1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque).

We have publications tested in 8 applications: Flow Cytometry, ICC, IHC, IHC-P, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using AF5726	Applications	Species
Marion Déjosez, Arturo Marin, Graham M. Hughes, Ariadna E. Morales, Carlos Godoy-Parejo, Jonathan L. Gray et al. Bat pluripotent stem cells reveal unusual entanglement between host and viruses Cell 2023-03-02 [PMID: 36812912]
M Moya-Jódar, A Ullate-Ago, P Barlabé, JR Rodríguez-, G Abizanda, C Barreda, X Carvajal-V, A Vilas-Zorn, JP Romero, L Garate, X Agirre, G Coppiello, F Prósper, XL Aranguren Revealing cell populations catching the early stages of human embryo development in naive pluripotent stem cell cultures Stem Cell Reports, 2022-12-22;0(0):. 2022-12-22 [PMID: 36563688] (ICC, Human)	ICC	Human
H Ozaki, H Suga, M Sakakibara, M Soen, N Miyake, T Miwata, S Taga, T Nagai, M Kano, K Mitsumoto, T Miyata, T Kobayashi, M Sugiyama, T Onoue, H Takagi, D Hagiwara, S Iwama, R Banno, G Iguchi, Y Takahashi, K Muguruma, H Inoue, H Arima Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state Scientific Reports, 2022-10-17;12(1):17381. 2022-10-17 [PMID: 36253431] (IHC, Human)	IHC	Human
M Zhang, J Ji, X Wang, X Zhang, Y Zhang, Y Li, X Wang, X Li, Q Ban, SD Ye The transcription factor TFCP2L1 promotes primordial germ cell-like cell specification of pluripotent stem cells The Journal of Biological Chemistry, 2021-09-21;0(0):101217. 2021-09-21 [PMID: 34555410] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Lindstrom NO, Sealfon R, Chen X et al. Spatial Transcriptional Mapping of the Human Nephrogenic Program Dev Cell 8/24/2021 [PMID: 34428401]
J Bayerl, M Ayyash, T Shani, YS Manor, O Gafni, R Massarwa, Y Kalma, A Aguilera-C, M Zerbib, H Amir, D Sheban, S Geula, N Mor, L Weinberger, S Naveh Tass, V Krupalnik, B Oldak, N Livnat, S Tarazi, S Tawil, E Wildschutz, S Ashouokhi, L Lasman, V Rotter, S Hanna, D Ben-Yosef, N Novershter, S Viukov, JH Hanna Principles of signaling pathway modulation for enhancing human naive pluripotency induction Cell Stem Cell, 2021-04-28;0(0):. 4/28/2021 [PMID: 33915080]
LTP Khoa, YC Tsan, F Mao, DM Kremer, P Sajjakulnu, L Zhang, B Zhou, X Tong, NV Bhanu, C Choudhary, BA Garcia, L Yin, GD Smith, TL Saunders, SL Bielas, CA Lyssiotis, Y Dou Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation Cell Stem Cell, 2020-06-30;0(0):. 2020-06-30 [PMID: 32610040] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
K Takahashi, D Jeong, S Wang, M Narita, X Jin, M Iwasaki, SD Perli, BR Conklin, S Yamanaka Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells Cell Rep, 2020-06-02;31(9):107715. 2020-06-02 [PMID: 32492424] (ICC, Human)	ICC	Human
Y Bi, Z Tu, Y Zhang, P Yang, M Guo, X Zhu, C Zhao, J Zhou, H Wang, Y Wang, S Gao Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation Cell Rep, 2020-03-17;30(11):3917-3931.e5. 2020-03-17 [PMID: 32187559] (Flow Cytometry, ICC, Western Blot, Human)	Flow Cytometry, ICC, Western Blot	Human
N Bredenkamp, J Yang, J Clarke, GG Stirparo, F von Meyenn, S Dietmann, D Baker, R Drummond, Y Ren, D Li, C Wu, M Rostovskay, S Eminli-Mei, A Smith, G Guo Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency Stem Cell Reports, 2019-11-07;13(6):1083-1098. 2019-11-07 [PMID: 31708477] (ICC, Human)	ICC	Human
Ransick, A, LindstrOm, N O Et al. Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney. Dev Cell 11/4/2019 [PMID: 31689386]
Hannah T. Stuart, Giuliano G. Stirparo, Tim Lohoff, Lawrence E. Bates, Masaki Kinoshita, Chee Y. Lim et al. Distinct Molecular Trajectories Converge to Induce Naive Pluripotency Cell Stem Cell 2019-09-05 [PMID: 31422912] (Immunohistochemistry, Immunocytochemistry, Human)	Immunohistochemistry, Immunocytochemistry	Human
DC Wan, SL Morgan, AL Spencley, N Mariano, EY Chang, G Shankar, Y Luo, TH Li, D Huh, SK Huynh, JM Garcia, CM Dovey, J Lumb, L Liu, KV Brown, A Bermudez, R Luong, H Zeng, VL Mascetti, SJ Pitteri, J Wang, H Tu, M Quarta, V Sebastiano, R Nusse, TA Rando, JE Carette, JF Bazan, KC Wang Honey bee Royalactin unlocks conserved pluripotency pathway in mammals Nat Commun, 2018-12-04;9(1):5078. 2018-12-04 [PMID: 30510260] (Western Blot, Mouse)	Western Blot	Mouse
Y Kang, Z Ai, K Duan, C Si, Y Wang, Y Zheng, J He, Y Yin, S Zhao, B Niu, X Zhu, L Liu, L Xiang, L Zhang, Y Niu, W Ji, T Li Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys Cell Rep, 2018-11-27;25(9):2563-2576.e9. 2018-11-27 [PMID: 30485820] (ICC, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	ICC	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
JL Sardina, S Collombet, TV Tian, A Gómez, B Di Stefano, C Berenguer, J Brumbaugh, R Stadhouder, C Segura-Mor, M Gut, IG Gut, S Heath, S Aranda, L Di Croce, K Hochedling, D Thieffry, T Graf Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate Cell Stem Cell, 2018-09-13;0(0):. 2018-09-13 [PMID: 30220521] (Immunoprecipitation, Mouse)	Immunoprecipitation	Mouse
S Rajderkar, C Panaretos, V Kaartinen Trim33 regulates early maturation of mouse embryoid bodies in vitro Biochem Biophys Rep, 2017-10-18;12(0):185-192. 2017-10-18 [PMID: 29090280] (IHC-P, Western Blot, Mouse)	IHC-P, Western Blot	Mouse
AJ Collier, SP Panula, JP Schell, P Chovanec, A Plaza Reye, S Petropoulo, AE Corcoran, R Walker, I Douagi, F Lanner, PJ Rugg-Gunn Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States Cell Stem Cell, 2017-03-23;0(0):. 3/23/2017 [PMID: 28343983]
Takashima Y, Guo G, Loos R et al. Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human. Cell 9/11/2014 [PMID: 25215486]
Paragas N, Kulkarni R, Werth M, Schmidt-Ott K, Forster C, Deng R, Zhang Q, Singer E, Klose A, Shen T, Francis K, Ray S, Vijayakumar S, Seward S, Bovino M, Xu K, Takabe Y, Amaral F, Mohan S, Wax R, Corbin K, Sanna-Cherchi S, Mori K, Johnson L, Nickolas T, D'Agati V, Lin C, Qiu A, Al-Awqati Q, Ratner A, Barasch J alpha-Intercalated cells defend the urinary system from bacterial infection. J Clin Invest, 2014-06-17;124(7):2963-76. 2014-06-17 [PMID: 24937428] (ICC, Mouse)	ICC	Mouse
Show All 19 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	ICC	Mouse	08/04/2016	View Summary Application Immunocytochemistry Sample Tested R1 wild type Mouse embryonic Stem Cells Species Mouse Lot CCUG0115021

Array AF5726

• TFCP2L1 Antibodies
• TFCP2L1 Lysate