TCF7/TCF1 Antibody (812145) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TCF7 (Transcription factor 7), also called TCF1 (T cell factor 1) is a member of the lymphoid enhancer binding factor family of proteins that is expressed in thymocytes and mature T cells. In resting cells, TCF family members are transcriptional repressors, and are 25‑32 kDa in size. Following activation, the large TCF7/TCF1 isoform (isoform 2, chosen as 'canonical') predominates (419 amino acids, 42‑50 kDa), and serves a transcriptional activator function. The use of an alternate start site at Met116 seems to characterize repressor isoforms. Within aa 61-116 of the large form, mouse TCF7/TCF1 shares 77% aa sequence identity with human TCF7/TCF1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using MAB8224	Applications	Species
Avishai Gavish, Benny Chain, Tomer M. Salame, Yaron E. Antebi, Shir Nevo, Shlomit Reich-Zeliger et al. From pseudo to real-time dynamics of T cell thymic differentiation iScience 2023-01-20 [PMID: 36624839]
Qiuyu Guo, Albert Kim, Bin Li, Andrew Ransick, Helena Bugacov, Xi Chen et al. A beta -catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells eLife 2021-02-15 [PMID: 33587034]
Jina Ko, Yongcheng Wang, Jonathan C. T. Carlson, Angela Marquard, Jeremy Gungabeesoon, Alain Charest et al. Single Extracellular Vesicle Protein Analysis Using Immuno‐Droplet Digital Polymerase Chain Reaction Amplification Advanced Biosystems 2020-12-01 [PMID: 33274611]

Array MAB8224

• TCF7/TCF1 Antibodies
• TCF7/TCF1 Proteins