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TACE/ADAM17 Antibody [DyLight 755]

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Product Details

Summary
Reactivity Hu, Rt, MuSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 755

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-77044AF350
Alexa Fluor 405
NBP1-77044AF405
Alexa Fluor 488
NBP1-77044AF488
Alexa Fluor 532
NBP1-77044AF532
Alexa Fluor 594
NBP1-77044AF594
Alexa Fluor 647
NBP1-77044AF647
Alexa Fluor 700
NBP1-77044AF700
Alexa Fluor 750
NBP1-77044AF750
Biotin
NBP1-77044B
CoraFluor 1
NBP1-77044CL1
DyLight 350
NBP1-77044UV
DyLight 405
NBP1-77044V
DyLight 488
NBP1-77044G
DyLight 550
NBP1-77044R
DyLight 594
NBP1-77044DL594
DyLight 650
NBP1-77044C
DyLight 680
NBP1-77044FR
FITC
NBP1-77044F
HRP
NBP1-77044H
Janelia Fluor 525
NBP1-77044JF525
Janelia Fluor 549
NBP1-77044JF549
Janelia Fluor 585
NBP1-77044JF585
Janelia Fluor 635
NBP1-77044JF635
Janelia Fluor 646
NBP1-77044JF646
Janelia Fluor 669
NBP1-77044JF669
PerCP
NBP1-77044PCP
Unconjugated
NBP1-77044
mFluor Violet 450 SE
NBP1-77044MFV450
mFluor Violet 500 SE
NBP1-77044MFV500
mFluor Violet 610 SE
NBP1-77044MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-77044
BSA Free
NBP1-77044
BSA Free
NBP1-77044-0.025mg
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TACE/ADAM17 Antibody [DyLight 755] Summary

Immunogen
Antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human TACE. The immunogen is located within the last 50 amino acids of TACE. Amino Acid Squence: ASFKLQRQNRVDSKETE
Specificity
80 to 130 kDa bands can be detected, which may represent mature protein, precursor, and glycosylated TACE/ADAM17. Human TACE/ADAM17 has 2 isoforms, including isoform A (824aa, 93kD), isoform B (694aa, 78.5kD). This antibody detects only isoform A. Mouse TACE/ADAM17 has 2 isoforms, long isoform (827aa, 93.1kD) and short isoform (655aa, 73.9kD). Rat TACE/ADAM17 has only one isoform identified so far (827aa, 93kD).
Predicted Species
Mouse (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ADAM17
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for TACE/ADAM17 Antibody [DyLight 755]

  • ADAM 17
  • ADAM metallopeptidase domain 17
  • ADAM metallopeptidase domain 18
  • ADAM17
  • ADAM18
  • CD156b antigen
  • CD156b
  • CSVP
  • disintegrin and metalloproteinase domain-containing protein 17
  • EC 3.4.24.86
  • MGC71942
  • Snake venom-like protease
  • TACE
  • TACEcSVP
  • TNF-alpha convertase
  • TNF-alpha converting enzyme
  • TNF-alpha-converting enzyme
  • tumor necrosis factor, alpha, converting enzyme

Background

ADAM17 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TACE/ADAM17
Antibody [DyLight 755
NBP1-77044IR
TACE/ADAM17 Antibody [DyLight 755]
Species: Hu, Rt, Mu
Applications: WB, ELISA, ICC/IF

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Bioinformatics

Gene Symbol ADAM17