Sulfatase-2/SULF2 Antibody (2B4) - BSA Free

Sulfatase 2 (SULF2) is a member of sulfatase family and catalyzes the removal of 6-O-sulfate groups from the heparan sulfate (HS) disaccharide units of heparan sulfate proteoglycans (HSPGs). HSPGs are present on the cell surface as well as in the extracellular matrix and act either as sequestration sites for growth factor/cytokine ligands or as coreceptors in multiple signal transduction pathways. SULF2 mediated desulfation of HSPGs is proposed to decrease the affinity of HSPGs for a variety of signaling ligands, releasing them from sequestration sites and making them available for triggering signaling stimuli. SULF2 is localized in endoplasmic reticulum, Golgi apparatus and also on the cell surface, and is expressed at highest levels in tissues such as ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta. In its post-translational modification, the conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. SULF2 enzyme regulates the activities of a number of signal transduction pathways which are up-regulated in many tissues during development and disease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IF/IHC, IHC-P, WB.

Showing Publications 1 - 6 of 6.

Publications using NBP1-36727	Applications	Species
Yue X. Epithelial Deletion of Sulf2 Exacerbates Bleomycin-induced Lung Injury, Inflammation and Mortality Am. J. Respir. Cell Mol. Biol. 2017-06-28 [PMID: 28657777] (IF/IHC, Mouse)	IF/IHC	Mouse
Zhu C, He L, Zhou X et al. Sulfatase 2 promotes breast cancer progression through regulating some tumor-related factors. Oncology reports. 2015-12-02 [PMID: 26708018] (WB, Human) Details: Sulf2 antibody used for WB on various breast cancer cell lines (MCF-7, MDA-MB-231, MDA-MB-468 and BT-549) and HBL-100 (mammary epithelial cell line) (Figure 1).	WB	Human
Solari V, Borriello L, Turcatel G et al. MYCN-dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival Cancer Res. 2014-08-27 [PMID: 25164011]
Yue X, Lu J, Auduong L et al. Overexpression of Sulf2 in idiopathic pulmonary fibrosis. Glycobiology 2013-02-14 [PMID: 23418199] (WB, Human)	WB	Human
Lui NS, van Zante A, Rosen SD et al. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study BMJ Open 2012-11-23 [PMID: 23180455] (IF/IHC, Human)	IF/IHC	Human
Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD. Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis. Oncogene;29(5):635-46. 2010-02-04 [PMID: 19855436] (WB, IHC-P, Human)	WB, IHC-P	Human

Array NBP1-36727

• Sulfatase-2/SULF2 Antibodies
• Sulfatase-2/SULF2 ELISA Kits
• Sulfatase-2/SULF2 Lysates
• Sulfatase-2/SULF2 Protein