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Sulfamidase/SGSH Antibody

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Orthogonal Strategies: Immunohistochemistry-Paraffin: Sulfamidase/SGSH Antibody [NBP1-83165] - Analysis in human adrenal gland and skeletal muscle tissues. Corresponding SGSH RNA-seq data are presented for the ...read more
Independent Antibodies: Immunohistochemistry-Paraffin: Sulfamidase/SGSH Antibody [NBP1-83165] - Staining of human adrenal gland, duodenum, kidney and skeletal muscle using Anti-SGSH antibody (A) NBP1-83165 shows ...read more
Immunohistochemistry-Paraffin: Sulfamidase/SGSH Antibody [NBP1-83165] - Staining of human adrenal gland shows strong cytoplasmic granular positivity in glandular cells.
Immunohistochemistry-Paraffin: Sulfamidase/SGSH Antibody [NBP1-83165] - Staining of human duodenum shows strong cytoplasmic granular positivity in glandular cells.
Immunohistochemistry-Paraffin: Sulfamidase/SGSH Antibody [NBP1-83165] - Staining of human kidney shows strong cytoplasmic granular positivity in cells in tubules.
Immunohistochemistry-Paraffin: Sulfamidase/SGSH Antibody [NBP1-83165] - Staining of human prostate shows strong cytoplasmic granular positivity in glandular cells.
Immunohistochemistry-Paraffin: Sulfamidase/SGSH Antibody [NBP1-83165] - Staining of human skeletal muscle shows very weak positivity in myocytes as expected.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Sulfamidase/SGSH Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: CEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPL
Predicted Species
Mouse (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SGSH
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200-1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
Sulfamidase/SGSH Protein (NBP1-83165PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Sulfamidase/SGSH Antibody

  • heparan sulfate sulfatase
  • HSS
  • HSSN-sulphoglucosamine sulphohydrolase
  • MPS3A
  • MPS3Asulphamidase
  • N-sulfoglucosamine sulfohydrolase
  • SFMD
  • SFMDEC 3.10.1.1
  • SGSH
  • Sulfamidase
  • Sulfoglucosamine sulfamidase
  • Sulphamidase

Background

SGSH encodes one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with Sanfilippo syndrome A, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SGSH