Staufen Antibody

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Block/Neutralize, In vivo assay, WB, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using NBP1-33202	Applications	Species
Paul S, Dansithong W, Gandelman M et al. Staufen Impairs Autophagy in Neurodegeneration Annals of Neurology 2023-02-01 [PMID: 36151701] (Western Blot, In vivo assay, Block/Neutralize)	Western Blot, In vivo assay, Block/Neutralize
Scoles DR, Gandelman M, Paul S et al. A quantitative high throughput screen identifies compounds that lower expression of the SCA2- and ALS-associated gene ATXN2 The Journal of biological chemistry 2022-07-01 [PMID: 35787375]
Gandelman M, Dansithong W, Kales SC et al. The AKT modulator A-443654 reduces ?-synuclein expression and normalizes ER stress and autophagy Journal of Biological Chemistry 2021-10-01 [PMID: 34520759] (Western Blot)	Western Blot
Paul S, Dansithong W, Figueroa KP et al. Staufen1 in human neurodegeneration Annals of neurology 2021-03-21 [PMID: 33745139]
Corbet GA, Burke JM, Bublitz GR, Parker R dsRNA-induced condensation of antiviral proteins promotes PKR activation J Biol Chem 2020-01-04 [PMID: 31896577]
Paul S, Dansithong W, Figueroa KP et al. Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration. Nat Commun 2018-09-07 [PMID: 30194296] (WB, Human)	WB	Human

Array NBP1-33202

• Staufen Antibodies
• Staufen Lysates
• Staufen Proteins