ST2/IL-33R Antibody (97203) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ST2, also known as IL-33R, IL-1 R4 and T1, is an Interleukin-1 receptor family glycoprotein that contributes to Th2 immune responses (1, 2). Human ST2 consists of a 310 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 207 aa cytoplasmic domain with an intracellular TIR domain (3, 4). Alternate splicing of the 120 kDa human ST2 generates a soluble 60 kDa isoform that lacks the transmembrane and cytoplasmic regions as well as an isoform that additionally lacks the third Ig‑like domain (4). Within the ECD, human ST2 shares 68% and 64% aa sequence identity with mouse and rat ST2, respectively. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes (5‑8). It binds IL-33, a cytokine that is upregulated by inflammation or mechanical strain in smooth muscle cells, airway epithelia, keratinocytes, and cardiac fibroblasts (5, 9). IL-33 binding induces the association of ST2 with IL-1R AcP, a shared signaling subunit that also associates with IL-1 RI and IL-1 R rp2 (1, 10, 11). In macrophages, ST2 interferes with signaling from IL-1 RI and TLR4 by sequestering the adaptor proteins MyD88 and Mal (7). In addition to its role in promoting mast cell and Th2 dependent inflammation, ST2 activation enhances antigen induced hypernociception and protects from atherosclerosis and cardiac hypertrophy (5, 12‑14). The soluble ST2 isoform is released by activated Th2 cells and strained cardiac myocytes and is elevated in the serum in allergic asthma (6, 8, 15). Soluble ST2 functions as a decoy receptor that blocks IL‑33's ability to signal through transmembrane ST2 (10, 13‑15).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 7 applications: AlphaLISA, Flow Cytometry, IHC-Fr, IHC-P, Mass Cytometry, Neutralization, Western Blot.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using MAB523	Applications	Species
MJ Camiolo, X Zhou, TB Oriss, Q Yan, M Gorry, W Horne, JB Trudeau, K Scholl, W Chen, JK Kolls, P Ray, FJ Weisel, NM Weisel, N Aghaeepour, K Nadeau, SE Wenzel, A Ray High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status Cell Reports, 2021-04-13;35(2):108974. 2021-04-13 [PMID: 33852838] (Flow Cytometry, Mass Cytometry, Human)	Flow Cytometry, Mass Cytometry	Human
Rui Zheng, Yang Chen, Jianbo Shi, Kai Wang, Xuekun Huang, Yueqi Sun et al. Combinatorial IL-17RB, ST2, and TSLPR Signaling in Dendritic Cells of Patients With Allergic Rhinitis Frontiers in Cell and Developmental Biology 2020-04-03 [PMID: 32309281]
Min Jiang, Simin Tao, Shaohua Zhang, Jing Wang, Fengbo Zhang, Fengsen Li et al. Type 2 innate lymphoid cells participate in IL‑33‑stimulated Th2‑associated immune response in chronic obstructive pulmonary disease Experimental and Therapeutic Medicine 2019-08-20 [PMID: 31572551]
AM Ramadan, E Daguindau, JC Rech, K Chinnaswam, J Zhang, GL Hura, B Griesenaue, Z Bolten, A Robida, M Larsen, JA Stuckey, CY Yang, S Paczesny From proteomics to discovery of first-in-class ST2 inhibitors active in vivo JCI Insight, 2018-07-26;3(14):. 2018-07-26 [PMID: 30046004] (AlphaLISA, Human)	AlphaLISA	Human
CW Wu, YG Wu, C Cheng, ZD Hong, ZM Shi, SQ Lin, J Li, XY He, AY Zhu Interleukin-33 Predicts Poor Prognosis and Promotes Renal Cell Carcinoma Cell Growth Through its Receptor ST2 and the JNK Signaling Pathway Cell. Physiol. Biochem., 2018-05-10;47(1):191-200. 2018-05-10 [PMID: 29763892] (Neutralization, Human)	Neutralization	Human
D Díaz-Jimén, L Núñez, M De la Fuen, K Dubois-Cam, H Sepúlveda, M Montecino, A Torres-Riq, P García-Gon, J Chnaiderma, A Vossenkamp, TT MacDonald, D Simian, MJ González, JA Cidlowski, R Quera, MA Hermoso A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis Sci Rep, 2017-08-31;7(1):10180. 2017-08-31 [PMID: 28860510] (IHC-P, Human)	IHC-P	Human
David Díaz-Jiménez, Marjorie De la Fuente, Karen Dubois-Camacho, Glauben Landskron, Janitza Fuentes, Tamara Pérez et al. Soluble ST2 is a sensitive clinical marker of ulcerative colitis evolution BMC Gastroenterology 2016-12-01 [PMID: 27565556]
Blom L, Poulsen L IL-1 Family Members IL-18 and IL-33 Upregulate the Inflammatory Potential of Differentiated Human Th1 and Th2 Cultures. J Immunol, 2012-10-01;189(9):4331-7. 2012-10-01 [PMID: 23028054] (Neutralization, Human)	Neutralization	Human
Sahlander K, Larsson K, Palmberg L Daily exposure to dust alters innate immunity. PLoS ONE, 2012-02-15;7(2):e31646. 2012-02-15 [PMID: 22355383] (Neutralization, Human)	Neutralization	Human
Kamekura R, Kojima T, Takano K, Go M, Sawada N, Himi T The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis. Clin. Exp. Allergy, 2012-02-01;42(2):218-28. 2012-02-01 [PMID: 22233535] (IHC-Fr, Neutralization, Human)	IHC-Fr, Neutralization	Human
Yasuo T, Kitaya K Effect of ovarian steroids on gene expression profile in human uterine microvascular endothelial cells. Fertil. Steril., 2008-08-09;92(2):709-21. 2008-08-09 [PMID: 18692832] (IHC-P, Western Blot, Human)	IHC-P, Western Blot	Human
Show All 11 Publications. Collapse Publications.

Array MAB523

• ST2/IL-33R Antibodies
• ST2/IL-33R Antibody Pair
• ST2/IL-33R ELISA Kit
• ST2/IL-33R Proteins
• ST2/IL-33R ELISAs
• ST2/IL-33R Proteins and Enzymes