Snail Antibody

Snail, also called SNAIL1 or SNAI1, is a zinc-finger transcription factor belonging to the Snail superfamily and encoded by the SNAI1 gene (1,2). Snail was first discovered in Drosophila and has homologs in many species including vertebrates and humans (1,2). The Snail family members includes Snail (Snail1), Slug (Snail2), and Smuc (Snail3) (1,2). In humans, Snail is expressed in a number of tissues including placenta, brain, and skeletal muscle, but is most highly expressed by the kidneys (1). Snail functions in repression of E-cadherin transcription which is associated with epithelial-mesenchymal transition (EMT) that is especially prominent during embryonic development (1-5). Along with Snail, other related EMT-inducing transcription factors (EMT-TFs) include the Twist and ZEB protein families (3). Snail is synthesized as a protein of 264 amino acids (aa) with an N-terminal SNAG domain, a serine-rich domain (SRD), nuclear export sequences (NES), and four C-terminal zinc-finger binding domains, with a theoretical molecular weight of 29 kDa (1,3). Snail activity is largely regulated through post-translational modifications such as phosphorylation, ubiquitination, and glycosylation, which impacts Snail's localization and stability, amongst other things (1-3, 5).

In addition to its role in embryonic development, Snail-induced EMT is also associated with cancer metastasis (1-5). Snail is expressed in a variety of cancer lines including breast cancer, cervical carcinoma, and colorectal carcinoma, and typically results in increased migration, invasion, and metastasis (1). Accordingly, Snail expression is also correlated with drug resistance and tumor recurrence (1-5). Chemical inhibitors that target Snail have shown some promise in reducing or eliminating Snail-induced EMT, increasing E-cadherin expression, and increasing tumor regression (1).

1. Kaufhold, S., & Bonavida, B. (2014). Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention. Journal of Experimental & Clinical Cancer Research. https://doi.org/10.1186/s13046-014-0062-0

2. Wang, Y., Shi, J., Chai, K., Ying, X., & Zhou, B. P. (2013). The Role of Snail in EMT and Tumorigenesis. Current Cancer Drug Targets. https://doi.org/10.2174/15680096113136660102

3. Kang, E., Seo, J., Yoon, H., & Cho, S. (2021). The Post-Translational Regulation of Epithelial-Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms22073591

4. Seo, J., Ha, J., Kang, E., & Cho, S. (2021). The role of epithelial-mesenchymal transition-regulating transcription factors in anti-cancer drug resistance. Archives of Pharmacal Research. https://doi.org/10.1007/s12272-021-01321-x

5. Baulida, J., Diaz, V. M., & Herreros, A. G. (2019). Snail1: A Transcriptional Factor Controlled at Multiple Levels. Journal of Clinical Medicine. https://doi.org/10.3390/jcm8060757

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC-P, Immunohistochemistry, WB.

Showing Publications 1 - 10 of 10.

Publications using NBP1-80022	Applications	Species
Han JH, Kim YK, Kim H et al. Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells Cancer communications (London, England) 2022-07-15 [PMID: 35838183] (IHC-P)	IHC-P
Rodriguez-Tirado C, Kale N, Carlini MJ et al. NR2F1 is a barrier to dissemination of early stage breast cancer cells Cancer research [PMID: 35471456] (ICC/IF, Mouse)	ICC/IF	Mouse
Belulescu IC, M?rg?ritescu C, Dumitrescu CI et al. The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas Romanian Journal of Morphology and Embryology 2021-04-10 [PMID: 33817718] (Immunohistochemistry)	Immunohistochemistry
Sad?ecki P, J�?wicki J, Antosik P, Walentowicz-Sad?ecka M. Expression of Selected Epithelial-Mesenchymal Transition Transcription Factors in Endometrial Cancer BioMed Research International 2020-12-29 [PMID: 33457409] (Immunohistochemistry)	Immunohistochemistry
Park JJ, Hah YS, Ryu S et al. Periostin Plays a Key Role in Radioresistance of Head and Neck Cancer Cells Via Epithelial-to-Mesenchymal Transition Anticancer Res. 2020-05-01 [PMID: 32366407] (ICC/IF)	ICC/IF
Hah YS, Cho HY, Jo SY et al. Nicotinamide N methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells Oncol. Rep. 2019-09-16 [PMID: 31545452] (WB, Human)	WB	Human
Marioni G, Cappellesso R, Ottaviano G et al. Nuclear nonmetastatic protein 23-H1 expression and epithelial-mesenchymal transition in laryngeal carcinoma: A pilot investigation. Head Neck 2018-06-28 [PMID: 29953715]
Sadlecki P, Jozwicki J et al. Expression of selected epithelial-mesenchymal transition transcription factors in serous borderline ovarian tumors and type I ovarian cancers. Tumour Biol 2018-01-06 [PMID: 29952249] (IF/IHC, Human)	IF/IHC	Human
Yang G, Zhao Z, Zhang X et al. Effect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the Notch/snail pathway in diabetic nephropathy model KKAy mice. Drug Des Devel Ther. 2017-04-14 [PMID: 28408805] (IHC-P, Mouse)	IHC-P	Mouse
Shirakawa T, Miyahara Y, Tanimura K. Expression of Epithelial-Mesenchymal Transition-related Factors in Adherent Placenta. International Journal of Gynecological Pathology. 2015-05-12 [PMID: 26447356]

Array NBP1-80022

• Snail Antibodies
• Snail ELISA Kits
• Snail Lysate
• Snail Proteins