Sirtuin 1/SIRT1 Antibody (834918) [Janelia Fluor® 585] Summary
Immunogen |
E. coli-derived recombinant human Sirtuin 1/SIRT1 Met1-Ser747 Accession # Q96EB6 |
Specificity |
Detects human Sirtuin 1/SIRT1 in ELISAs.
In direct ELISAs, no cross-reactivity
with recombinant human Sirtuin 2, 3, 5, or 6 is observed. |
Isotype |
IgG1 |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
SIRT1 |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- CyTOF-ready
- Immunocytochemistry
- Intracellular Staining by Flow Cytometry
|
Application Notes |
Optimal dilution of this antibody should be experimentally determined. |
Packaging, Storage & Formulations
Storage |
Store at 4C in the dark. |
Buffer |
50mM Sodium Borate |
Preservative |
0.05% Sodium Azide |
Notes
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
Alternate Names for Sirtuin 1/SIRT1 Antibody (834918) [Janelia Fluor® 585]
Background
The S. cerevisiae silent information regulator 2 (Sir2) protein is an NAD+-dependent histone deacetylase (HDACs) that plays a critical role in transcriptional silencing, genome stability, and longevity (1-2). Part of the Sirtuin family (Sir2, Sir3, Sir3), yeast Sir2 is the founding member of Class III HDACs. A human homologue of Sir2 , SIRT1, regulates the activity of the p53 tumor suppressor and inhibits apoptosis (3-4).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for Sirtuin 1/SIRT1 Antibody (FAB7714JF585) (0)
Secondary Antibodies
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