Siglec-8 Antibody (837535) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Siglec-8 (Sialic acid-binding Ig-like lectin 8), formerly called SAF-2 (sialoadhesin family member 2) and designated CD329, is a 75 kDa member of the inhibitory CD33‑related SIGLEC family within the Ig superfamily of proteins. An alternately spliced 48 kDa short form lacks most of the intracellular domain, while another isoform lacks the second of three extracellular Ig domains, representing amino acids (aa) 152-245 of the 499 aa long form. Siglec-8 is expressed exclusively on eosinophils, mast cells, and weakly on basophils, and is a marker for eosinophil terminal differentiation. It specifically recognizes 6’ sulfated sialyl Lewis X carbohydrate structures. Engagement results in eosinophils apoptosis, or mast cell inhibition of degranulation. Eosinophil Siglec F is the mouse paralog of human Siglec-8, but shares <40% amino acid sequence identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 4 of 4.

Publications using FAB7975P	Applications	Species
A Dietschman, S Schruefer, S Westermann, F Henkel, K Castiglion, R Willebrand, J Adam, J Ruland, R Lang, DC Sheppard, J Esser-von-, D Radtke, S Krappmann, D Voehringer Phosphatidylinositol 3-Kinase (PI3K) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type-Lectin Receptor (CLR) Signaling MBio, 2022-06-13;0(0):e0123922. 2022-06-13 [PMID: 35695427] (Flow Cytometry, Human)	Flow Cytometry	Human
Bavithra Vijayakumar, Karim Boustani, Patricia P. Ogger, Artemis Papadaki, James Tonkin, Christopher M. Orton et al. Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease Immunity 3/8/2022 [PMID: 35151371]
Stefanie Westermann, Axel Dietschmann, Daniela Doehler, Kirstin Castiglione, Bruce S. Bochner, David Voehringer et al. Siglec-F Promotes IL-33–Induced Cytokine Release from Bone Marrow–Derived Eosinophils Independently of the ITIM and ITIM-like Motif Phosphorylation The Journal of Immunology 2/1/2022 [PMID: 34996839]
BA Youngblood, EC Brock, J Leung, R Falahati, BS Bochner, HS Rasmussen, K Peterson, C Bebbington, N Tomasevic Siglec-8 antibody reduces eosinophil and mast cell infiltration in a transgenic mouse model of eosinophilic gastroenteritis JCI Insight, 2019-10-03;0(0):. 2019-10-03 [PMID: 31465299] (Flow Cytometry, Human)	Flow Cytometry	Human

Array FAB7975P

• Siglec-8 Antibodies
• Siglec-8 ELISA Kits
• Siglec-8 Lysate
• Siglec-8 Protein
• Siglec-8 Proteins and Enzyme