SHP-1 Antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB100-60553	Applications	Species
Dubois MJ, Bergeron S, Kim HJ et al. The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. Nat Med 2006-05-01 [PMID: 16617349]

Array NB100-60553

• SHP-1 Antibodies
• SHP-1 Antibody Pair
• SHP-1 ELISA Kits
• SHP-1 Lysates
• SHP-1 Protein
• SHP-1 Proteins and Enzyme