SHC1 Antibody (725001)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

SH2 domain-containing transforming protein C1 (SHC1), also known as ShcA, is a cytoplasmic adaptor protein that is important in the signal transduction from growth factor, cytokine, and lymphocyte antigen receptors. SHC1 contains a PTB/PID domain (aa 156-339), a collagen homology domain (aa 340-487), and an SH2 domain (aa 488-579). Alternate splicing generates additional isoforms that differ in the extent of N-terminal truncation. Activation of SHC1 by phosphorylation at Ser239, Ser240, and Tyr317 enables Shc1 to interact with the GRB2/SOS complex, leading to the transcription of genes involved in mitogenesis and apoptosis. The p46 and p52 isoforms promote mitogenic signaling, while the p66 isoform promotes apoptosis and functions as a negative regulator of SHC1-mediated mitogenic signal transduction. Within aa 488-579, human SHC1 shares 100% aa sequence identity with mouse and rat SHC1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using MAB7129	Applications	Species
JL Bailey, H Hang, A Boudreau, CM Elks Oncostatin M Induces Lipolysis and Suppresses Insulin Response in 3T3-L1 Adipocytes International Journal of Molecular Sciences, 2022-04-23;23(9):. 2022-04-23 [PMID: 35563078] (Western Blot, Mouse)	Western Blot	Mouse

Array MAB7129

• SHC1 Antibodies
• SHC1 ELISA Kits
• SHC1 Lysate
• SHC1 Proteins