Semaphorin 4A Antibody (757129)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Semaphorin 4A (Sema4A, previously semB) is type I transmembrane protein that is a Class 4 transmembrane Semaphorin with activity in the immune and nervous systems. It is expressed by dendritic cells, monocytes, T cells, B cells, astrocytes and oligodendrocytes, plus visceral smooth muscle and bronchial epithelial cells. The 760 amino acid (aa) mouse Sema4A contains a 650 aa extracellular domain (ECD, aa 33-682) with Sema, PSI and C2-type immunoglobulin domains. It interacts with B and D1 Plexins and lymphocyte TIM-2, enhancing dendritic cell-mediated T cell priming and Th1 responses. Sema4A interaction with endothelial cell plexin-D1 downregulates the actions of VEGF. Mutations of Sema4A are associated with retinitis pigmentosa and cone rod dystrophy in humans. Mouse Sema4A ECD shares 87% and 94% aa sequence identity with human and rat Sema4A, respectively, and shares approximately 35% aa identity with other Sema4 family members. Using this antibody, Sema4A has been shown to interact with Neuropilin-1 in vitro and in vivo to potentiate Treg cell function and survival.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using MAB8166	Applications	Species
Delgoffe , Greg M, Woo , Seng-Ryo, Turnis , Meghan E, Gravano , David M, Guy , Cliff, Overacre , Abigail, Bettini , Matthew, Vogel , Peter, Finkelstein , David, Bonnevier , Jody, Workman , Creg J, Vignali , Dario A Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature, 2013-08-04;501(7466):252-6. 2013-08-04 [PMID: 23913274]

Array MAB8166

• Semaphorin 4A Antibodies
• Semaphorin 4A Lysate
• Semaphorin 4A Proteins
• Semaphorin 4A Proteins and Enzyme