Sec8 Antibody (14G1)

rSec6 and rSec8 are rat homologs of the yeast Sec6 and Sec8 proteins that are essential for protein transport between the Golgi apparatus and the plasma membrane. In yeast, Sec8 is part of a 19.5S complex that includes Sec6 and Sec15, that also associate with the ras-like GTP binding protein Sec4. An analogous 17S complex in rat brain was found to contain rSec6 and rSec8, along with eight proteins with a combined molecular weight of 743 kDa. The membrane-associated rSec6/8 complex co-immunoprecipitates with syntaxin, providing evidence that this complex is involved in synaptic vesicle docking and fusion at the presynaptic terminal.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Mouse, Rat, Canine.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-97492	Applications	Species
M Knepper et al. Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct. Am. J. Physiol.Cell Physiol. 295, C661 . 2008-01-01 [PMID: 18596208] (WB, Rat)	WB	Rat
B Margolis et al. PALS1 regulates E-cadherin trafficking in mammalian epithelial cells. Mol. Biol. Cell 18, 874 . 2007-01-01 [PMID: 17182851] (ICC/IF, WB, Canine)	ICC/IF, WB	Canine
TJ Turner et al. Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. Mol. Cell. Biol. 22, 1714 . 2002-01-01 [PMID: 11865051] (WB, Mouse)	WB	Mouse

Array NBP1-97492

• Sec8 Antibodies
• Sec8 Lysate
• Sec8 Proteins