Western Blot: S1P4/EDG-6 Antibody [NBP2-24500] - Analysis of EDG6 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide and 3) RAW using NBP2-24500 at 4.0 ug/ml.
Immunohistochemistry-Paraffin: S1P4/EDG-6 Antibody [NBP2-24500] - Analysis of Edg6/S1P4 in paraffin-embedded formalin-fixed mouse RAW cells using an isotype control (top) and this antibody (bottom) at 5 ug/ml.
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor6,endothelial differentiation, G protein coupled receptor 6
S1P receptor 4
S1P4
S1P4LPC1
S1PR4
SLP4
sphingosine 1-phosphate receptor 4
Sphingosine 1-phosphate receptor Edg-6
sphingosine-1-phosphate receptor 4
Background
EDG6, a Lysophospholipid/Lysosphingolipid Receptor, may regulate lymphocyte cell signaling. EDG6 is activated by sphingosine-1-phosphate. EDG6 has been reported in fetal and adult lymphoid and hematopoietic tissues (Graler et al, 1998) as well as in rat lung and Burkitt lymphoma cell lines. Contrary to other receptors of the EDG family, EDG6 is not expressed in the nervous system.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Publications for S1P4/EDG-6 Antibody (NBP2-24500)(1)
We have publications tested in 1 confirmed species: Mouse.
We have publications tested in 1 application: WB.
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Publication using NBP2-24500
Applications
Species
Lee K, Koh E, Hong C et al. A novel S1PR4 functional antagonist prevents nonalcoholic steatohepatitis by deactivating the NLRP3 inflammasome without causing lymphopenia Research Square 2020-11-13 (WB, Mouse)
WB
Mouse
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