RNF40 Antibody

The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes and the ligation of ubiquitin to the target protein by E3 enzymes. Ring finger protein 40 (RNF40) is a member of the RING type E3 ubiquitin ligases. RNF40 forms a complex with RNF20 to carry out H2B monoubiquitination in association with hPAF and the UbcH6 ubiquitin E2-conjugating enzyme. H2B monoubiquitination by RN40/RNF20 has been shown to be associated with increased H3 methylation and gene transcription. Alternate names for RNF40 include E3 ubiquitin-protein ligase BRE1B, BRE1-B, 95kDa retinoblastoma-associated protein, RBP95, STARING, KIAA0661, MGC13051, and DKFZp686K191.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publication 1 - 1 of 1.

Publication using NB100-2247	Applications	Species
Lyu Y, Yang Y, Talwar V et al Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes Cell Rep 2024-03-22 [PMID: 38517892] (WB, Human)	WB	Human

Array NB100-2247

• RNF40 Antibodies
• RNF40 Lysate
• RNF40 Proteins