RNF20 Antibody - BSA Free

The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes, and the ligation of ubiquitin to the target protein by E3 enzymes. Ring finger protein 20 (RNF20) is a member of the RING type E3 ubiquitin ligases. RNF20 forms a complex with RNF40 to carry out H2B monoubiquitination in association with hPAF and the UbcH6 ubiquitin E2-conjugating enzyme. H2B monoubiquitination by RNF40/RNF20 has been shown to be associated with increased H3 methylation and gene transcription. Alternate names for RNF20 include E3 ubiquitin-protein ligase BRE1A, BRE1-A, hBRE1, FLJ11189, FLJ20382, KIAA2779, MGC129667, and MGC129668.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: Chemotaxis, WB.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using NB100-2242	Applications	Species
Lyu Y, Yang Y, Talwar V et al Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes Cell Rep 2024-03-22 [PMID: 38517892] (WB, Human)	WB	Human
Cortez JT, Montauti E, Shifrut E et al. CRISPR screen in regulatory T cells reveals modulators of Foxp3 Nature 2020-06-18 [PMID: 32499641]
Chen S, Jing Y, Kang X et al. Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy. Nucleic Acids Res 2017-02-17 [PMID: 28180298]
Chen S, Jing Y, Kang X et al. Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy. Nucleic Acids Res. 2016-10-26 [PMID: 27789696] (WB, Human)	WB	Human
Wu Y, Chen P, Jing Y et al. Microarray Analysis Reveals Potential Biological Functions of Histone H2B Monoubiquitination PLoS ONE. 2015-07-16 [PMID: 26177367] (WB, Human)	WB	Human
Sussman RT, Stanek TJ, Esteso P et al. The epigenetic modifier Ubiquitin Specific Protease 22 (Usp22) regulates embryonic stem cell differentiation via transcriptional repression of Sex determining region Y-box 2 (Sox2). J Biol Chem 2013-06-12 [PMID: 23760504] (WB, Mouse)	WB	Mouse
Wang E, Kawaoka S, Yu M et al. Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proc Natl Acad Sci U S A 2013-03-05 [PMID: 23412334] (WB, Human)	WB	Human
Arora M, Zhang J, Heine GF et al. Promoters active in interphase are bookmarked during mitosis by ubiquitination Nucleic Acids Res 2012-08-31 [PMID: 22941662] (WB, Human)	WB	Human
Jaaskelainen T, Makkonen H, Visakorpi T et al. Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth. Mol Cell Endocrinol 2012-03-01 [PMID: 22155569]
Hahn MA, Dickson KA, Jackson S et al. The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination. Hum Mol Genet 2012-02-01 [PMID: 22021426]
Taniue K, Oda T, Hayashi T et al. A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis. EMBO Rep 2011-07-01 [PMID: 21617703] (Chemotaxis, Human)	Chemotaxis	Human
Kim J, Roeder RG. Nucleosomal H2B ubiquitylation with purified factors. Methods 2011-07-01 [PMID: 21443952]
Buro LJ, Chipumuro E, Henriksen MA. Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1). Epigenetics Chromatin. 2010-09-08 [PMID: 20825659] (WB, Human)	WB	Human
Wu J, Huen MS, Lu LY et al. Histone ubiquitination associates with BRCA1-dependent DNA damage response. Mol Cell Biol 2009-02-01 [PMID: 19015238]
Shema E, Tirosh I, Aylon Y et al. The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes amp; Dev;22(19):2664-2676. 2008-01-01 [PMID: 18832071]
Show All 15 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Mansi Arora	WB	Human	05/16/2012	View Summary Application Western Blot Sample Tested Hela whole cell lysate Species Human Lot A1

Array NB100-2242

• RNF20 Antibodies
• RNF20 Lysate
• RNF20 Protein