Rheb Antibody (2C11)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 applications: IP, WB.

Showing Publications 1 - 10 of 10.

Publications using H00006009-M01	Applications	Species
Gianluca F, Sandra M, Anna H et al. Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition. Nat Cell Biol. 2022-09-12 [PMID: 36097071]
Yanghao Z, Xin Z, Kun-Liang G et al. Rheb regulates nuclear mTORC1 activity independent of farnesylation. Cell Chem Biol. 2022-03-15 [PMID: 35294906]
Yao Y, Hong S, Ikeda T et al. Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity Molecular Cell 2020-11-01 [PMID: 33157014] (IP, WB)	IP, WB
Jewell J, Fu V, Hong A et al. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife. 2019-05-21 [PMID: 31112131]
Deng L, Chen L, Zhao L et al. Ubiquitination of Rheb governs growth factor-induced mTORC1 activation. Cell Res 2018-12-04 [PMID: 30514904]
Hoxhaj G, Hughes-Hallett J, Timson RC et al. The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels. Cell Rep 2017-10-31 [PMID: 29091770]
Tian Q, Gromov P, Clement JH et al. RHEB1 insufficiency in aged male mice is associated with stress-induced seizures. Geroscience 2017-09-10 [PMID: 28891034]
Jacobs BL, McNally RM, Kim KJ et al. Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signaling. J Biol Chem 2017-03-13 [PMID: 28289099]
Agarwal S, Bell CM, Taylor SM, Moran RG. p53 Deletion or Hot-spot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2015-09-18 [PMID: 26385560]
Menon S, Dibble CC, Talbott G et al. Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome. Cell. 2014-02-13 [PMID: 24529379]

Array H00006009-M01

• Rheb Antibodies
• Rheb Lysate
• Rheb Proteins