Recombinant Mouse PDGF-D Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The platelet-derived growth factor (PDGF) family consists of four disulfide-linked homodimers and one heterodimer (PDGF-AB). These proteins regulate diverse cellular functions through interactions with PDGF R alpha and R beta (1, 2). Mature PDGF-DD associates with PDGF R beta and triggers signaling through PDGF R beta homodimers and PDGF R alpha / beta heterodimers (3-5). The mouse PDGF-DD cDNA encodes a 370 amino acid (aa) precursor that includes a 23 aa signal sequence, a 226 aa CUB domain, and a 121 aa PDGF/VEGF domain (3, 4). The PDGF/VEGF domain shares 27-35% aa sequence identity with the corresponding regions of other PDGF family members. Mouse PDGF-DD shares 91% and 98% aa sequence identity with human and rat PDGF-DD, respectively. PDGF-DD is secreted as a 100 kDa latent homodimer which is activated by proteolysis to release a 35 kDa bioactive protein containing the disulfide-linked dimer of PDGF/VEGF domain (3, 4, 6, 7). A splice variant of PDGF-DD has a 6 aa deletion near the N-terminus. A 72 aa deletion within the PDGF/VEGF domain generates an inactive protein in mouse but has not been detected in human (8). PDGF-DD is widely expressed in embryonic and adult tissues (3, 9, 10), and PDGF R beta is expressed in a generally complementary pattern (9, 11, 12). PDGF-DD functions as a growth factor for renal artery smooth muscle cells and lens epithelial cells, and as a macrophage chemoattractant (5, 9-11). PDGF-DD is over-expressed in and contributes to several disease states, including renal and hepatic fibrosis, mesangial proliferative glomerulopathy, pulmonary lymphoid infiltration, and many cancers (6, 11-15). PDGF-DD functions in both paracrine and autocrine manners (6, 7, 14).

Array 9738-SB

• PDGF-D/SCDGFB Antibodies
• PDGF-D/SCDGFB ELISA Kits
• PDGF-D/SCDGFB Lysates
• PDGF-D/SCDGFB Proteins
• PDGF-D/SCDGFB Proteins and Enzyme