Recombinant Mouse FSH alpha/beta Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Follicle-Stimulating Hormone (FSH) beta is one of the components of the heterodimeric glycoprotein hormone FSH. FSH is composed of noncovalently linked glycosylated alpha  and beta  chains. The alpha  subunit is also a component of Luteinizing Hormone (LH), Thyroid-Stimulating Hormone, and Chorionic Gonadotropin. The unique beta  subunit confers the protein’s specific biological action and is responsible for the interaction with the FSH Receptor (1-3). The approximately 21 kDa mouse FSH  beta subunit shares 85% and 95% aa sequence identity with the human and rat orthologs, respectively. FSH is produced and secreted by the anterior pituitary gland. Its secretion is controlled by Gonadotropin-Releasing Hormone from the hypothalamus; however, FSH secretion can also be stimulated by activins and inhibited by inhibins (4-6). FSH works in concert with LH to regulate female reproduction; FSH stimulates follicular growth and LH induces ovulation (7). FSH can also regulate estrogen formation by inducing the aromatase enzyme that converts androgen to estradiol (7, 8). In addition, it has been suggested to have a role in postmenopausal bone loss and in the neovascularization surrounding malignant tumors (9-11). In males, FSH is critical for sperm production (12). Mutations in the human FSH and FSHR genes are associated with reduced reproductive functioning in females (2, 11). Additionally, increased production of autoantibodies directed against FSH beta has been suggested to contribute to certain types of female infertility (2). Assisted reproductive technology commonly uses recombinant FSH to induce follicle growth (7).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, Cell Culture.

Showing Publications 1 - 4 of 4.

Publications using 8576-FS/CF	Applications	Species
L Bordás, B Somosk?i, D Török, BN Vincze, S Cseh Post-thaw viability of mouse preantral follicles after cryopreservation with cryotube freezing and OPS vitrification procedures Reproductive biology, 2023-03-09;23(2):100752. 2023-03-09 [PMID: 36905824] (Bioassay, Mouse)	Bioassay	Mouse
S Zhou, Y Xi, Y Chen, F Fu, W Yan, M Li, Y Wu, A Luo, Y Li, S Wang Low WIP1 Expression Accelerates Ovarian Aging by Promoting Follicular Atresia and Primordial Follicle Activation Cells, 2022-12-03;11(23):. 2022-12-03 [PMID: 36497179] (Cell Culture, Mouse)	Cell Culture	Mouse
T Wu, YY Gao, XN Tang, JJ Zhang, SX Wang Construction of Artificial Ovaries with Decellularized Porcine Scaffold and Its Elicited Immune Response after Xenotransplantation in Mice Journal of functional biomaterials, 2022-09-28;13(4):. 2022-09-28 [PMID: 36278634] (Bioassay, Mouse)	Bioassay	Mouse
Z Huan, Y Wang, M Zhang, X Zhang, Y Liu, L Kong, J Xu Follicle-stimulating hormone worsens osteoarthritis by causing inflammation and chondrocyte dedifferentiation FEBS Open Bio, 2021-06-27;0(0):. 2021-06-27 [PMID: 34176242] (Bioassay, Mouse)	Bioassay	Mouse

Array 8576-FS/CF

• FSH alpha/beta ELISA Kits
• FSH alpha/beta Proteins and Enzymes