Recombinant Mouse Ephrin-A5 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Ephrin‑A5, also known as AL‑1, RAGS, and LERK‑7, is an approximately 25 kDa member of the Ephrin‑A family of GPI‑anchored ligands that bind and induce the tyrosine autophosphorylation of Eph receptors. Ephrin‑A ligands are structurally related to the extracellular domains of the transmembrane Ephrin‑B ligands. Eph‑Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression (1, 2). Ephrin‑A5 preferentially interacts with receptors in the EphA family but also with EphB2 (3). Mature mouse Ephrin‑A5 shares 98.9% and 99.5% aa sequence identity with human and rat Ephrin‑A5 (4). Alternate splicing of mouse Ephrin‑A5 generates a short isoform that lacks 27 amino acids in the juxtamembrane region. The short isoform retains the ability to bind EphA3 and inhibit neurite extension (5). Ephrin‑A5 is expressed in multiple tissues during development, particularly in the brain (6, 7). It can exert repulsive or attractive effects on migrating neurons in the developing brain and motor column of the spinal cord (7‑11). Ephrin‑A5 repels migrating axons by inducing growth cone collapse and neurite retraction and by inhibiting the neurotrophic effects of NGF and BDNF (3, 12, 13). It interacts in cis with EphA3 on retinal axon growth cones which reduces axonal sensitivity to Ephrin‑A5 in trans (14). In the adult, Ephrin‑A5 is expressed on hippocampal neurons and astrocytes and induces the development of hippocampal synapses (10, 15, 16). It supports the proliferation of neural progenitors and the survival of newly differentiated neurons (15). Ephrin‑A5 functions as a tumor suppressor and its normal function in inhibiting EGFR signaling is compromised by its down‑regulation in glioma (17). Ephrin A5 is also down‑regulated in prostate cancer (18). Ephrin‑A5 is expressed by muscle precursor cells and interacts with EphA4 to restrict their migration to the correct locations during forelimb morphogenesis (19).

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 3 applications: Binding Assay, Bioassay, In Vivo.

Showing Publications 1 - 9 of 9.

Publications using 7396-EA	Applications	Species
Asadi, F;Gunawardana, SC;Dolle, RE;Piston, DW; An orally available compound suppresses glucagon hypersecretion and normalizes hyperglycemia in type 1 diabetes JCI insight 2024-01-23 [PMID: 38258903] (Binding Assay, Mouse)	Binding Assay	Mouse
Baudet, S;Zagar, Y;Roche, F;Gomez-Bravo, C;Couvet, S;Bécret, J;Belle, M;Vougny, J;Uthayasuthan, S;Ros, O;Nicol, X; Subcellular second messenger networks drive distinct repellent-induced axon behaviors Nature communications 2023-06-27 [PMID: 37369692] (Bioassay, Mouse)	Bioassay	Mouse
O Ros, Y Zagar, S Ribes, S Baudet, K Loulier, S Couvet, D Ladarre, A Aghaie, A Louail, C Petit, Y Mechulam, Z Lenkei, X Nicol SponGee: A Genetic Tool for Subcellular and Cell-Specific cGMP Manipulation Cell Rep, 2019-06-25;27(13):4003-4012.e6. 2019-06-25 [PMID: 31242429] (Bioassay, Mouse)	Bioassay	Mouse
V Mohan, SD Wade, CS Sullivan, MR Kasten, C Sweetman, R Stewart, Y Truong, M Schachner, PB Manis, PF Maness Close Homolog of L1 Regulates Dendritic Spine Density in the Mouse Cerebral Cortex through Semaphorin 3B J. Neurosci., 2019-06-10;0(0):. 2019-06-10 [PMID: 31182634] (Bioassay, Mouse)	Bioassay	Mouse
YH Liu, JW Tsai, JL Chen, WS Yang, PC Chang, PL Cheng, DL Turner, Y Yanagawa, TW Wang, JY Yu Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon Sci Rep, 2017-03-09;7(0):42895. 2017-03-09 [PMID: 28276447] (Bioassay, Rat)	Bioassay	Rat
EphA4 may contribute to microvessel remodeling in the hippocampal CA1 and CA3 areas in a mouse model of temporal lobe epilepsy Mol Med Rep, 2016-12-09;0(0):. 2016-12-09 [PMID: 27959424] (In Vivo, Mouse)	In Vivo	Mouse
K Gerstmann, D Pensold, J Symmank, M Khundadze, CA Hübner, J Bolz, G Zimmer Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions Development, 2014-12-05;142(1):140-50. 2014-12-05 [PMID: 25480914] (Bioassay, Mouse)	Bioassay	Mouse
Bouche E, Romero-Ortega M, Henkemeyer M, Catchpole T, Leemhuis J, Frotscher M, May P, Herz J, Bock H Reelin induces EphB activation. Cell Res, 2013-01-15;23(4):473-90. 2013-01-15 [PMID: 23318582] (Bioassay, Mouse)	Bioassay	Mouse
Polysialylated NCAM and EphrinA/EphA Regulate Synaptic Development of GABAergic Interneurons in Prefrontal Cortex [PMID: 22275477] (Bioassay, Mouse)	Bioassay	Mouse

Array 7396-EA

• Ephrin-A5 Antibodies
• Ephrin-A5 ELISA Kit
• Ephrin-A5 Lysate
• Ephrin-A5 Protein
• Ephrin-A5 Proteins and Enzymes