Recombinant Human Ephrin-A3 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Ephrin‑A3, also known as EHK1‑L, EFL‑2, and LERK‑3, is an approximately 25 kDa member of the Ephrin‑A family of GPI‑anchored ligands that bind and induce the tyrosine autophosphorylation of Eph receptors. Ephrin‑A ligands are structurally related to the extracellular domains of the transmembrane Ephrin‑B ligands. Eph‑Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. Ephrin‑A3 preferentially interacts with receptors in the EphA family (1, 2). Ephrin‑A3 is an unusual Ephrin‑A molecule in its dependence on heparan sulfate binding for full activity (3). Mature human Ephrin‑A3 shares 92% aa sequence identity with mouse and rat Ephrin‑A3 (4). Its expression is restricted to discreet locations during the early development of multiple tissues (5). Ephrin‑A3 expression can be up‑ or down‑regulated by hypoxia in the hippocampus or vascular endothelial cells, respectively (6, 7). Ephrin‑A3 down‑regulation contributes to hypoxia‑induced endothelial cell chemotaxis, proliferation, and tubule formation (7). Its interaction with EphA receptors induces neurite growth cone collapse and the repulsion of migrating axons (8‑10). This activity is important for the accurate pathfinding of migrating axons during CNS development (10). Astrocyte‑expressed Ephrin‑A3 activates EphA4 on hippocampal neurons to regulate dendritic spine morphology and long term potentiation (8, 11, 12). The same interaction induces reverse signaling through Ephrin‑A3 to regulate glutamate uptake by the astrocyte and the availability of glutamate in the synapse (11, 12). Astrocyte‑expressed Ephrin‑A3 also interacts with EphA7 to inhibit the proliferation of neural progenitor cells (13).

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Virus - Henipavirus.

We have publications tested in 3 applications: Bioassay, Cell Culture, Coprecipitation Assay.

Showing Publications 1 - 10 of 10.

Publications using 359-EA	Applications	Species
YL Chen, YC Yen, CW Jang, SH Wang, HT Huang, CH Chen, JR Hsiao, JY Chang, YW Chen Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells Scientific Reports, 2021-01-12;11(1):644. 2021-01-12 [PMID: 33436772] (Human)		Human
ED Laing, CK Navaratnar, S Cheliout D, SR Petzing, Y Xu, SL Sterling, GA Marsh, LF Wang, M Amaya, DB Nikolov, R Cattaneo, CC Broder, K Xu Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus Proc. Natl. Acad. Sci. U.S.A., 2019-09-23;0(0):. 2019-09-23 [PMID: 31548390] (Coprecipitation Assay, Virus - Henipavirus)	Coprecipitation Assay	Virus - Henipavirus
Sharonov G, Bocharov E, Kolosov P, Astapova M, Arseniev A, Feofanov A Point mutations in dimerization motifs of the transmembrane domain stabilize active or inactive state of the EphA2 receptor tyrosine kinase. J Biol Chem, 2014-04-14;289(21):14955-64. 2014-04-14 [PMID: 24733396] (Bioassay, Human)	Bioassay	Human
Falivelli , Giulia, Lisabeth , Erika Ma, Rubio de la Torre , Elena, Perez-Tenorio , Gizeh, Tosato , Giovanna, Salvucci , Ombretta, Pasquale , Elena B Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands. PLoS ONE, 2013-11-29;8(11):e81445. 2013-11-29 [PMID: 24348920] (Cell Culture, Human)	Cell Culture	Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)	Bioassay	Human
Afshari FT, Kwok JC, Fawcett JW Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling. J. Neurosci., 2010-03-24;30(12):4246-55. 2010-03-24 [PMID: 20335460] (Bioassay, Rat)	Bioassay	Rat
Inoue E, Deguchi-Tawarada M, Togawa A, Matsui C, Arita K, Katahira-Tayama S, Sato T, Yamauchi E, Oda Y, Takai Y Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation. J. Cell Biol., 2009-05-04;185(3):551-64. 2009-05-04 [PMID: 19414612] (Bioassay, Rat)	Bioassay	Rat
Nestor MW, Mok LP, Tulapurkar ME, Thompson SM Plasticity of neuron-glial interactions mediated by astrocytic EphARs. J. Neurosci., 2007-11-21;27(47):12817-28. 2007-11-21 [PMID: 18032653] (Bioassay, Mouse)	Bioassay	Mouse
Sharfe N, Freywald A, Toro A, Dadi H, Roifman C Ephrin stimulation modulates T cell chemotaxis. Eur. J. Immunol., 2002-12-01;32(12):3745-55. 2002-12-01 [PMID: 12516569] (Bioassay, Human)	Bioassay	Human
Murai KK, Nguyen LN, Irie F, Yamaguchi Y, Pasquale EB Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat. Neurosci., 2003-02-01;6(2):153-60. 2003-02-01 [PMID: 12496762] (Bioassay, Mouse)	Bioassay	Mouse

Array 359-EA

• Ephrin-A3 Antibodies
• Ephrin-A3 ELISA Kit
• Ephrin-A3 Protein
• Ephrin-A3 Proteins and Enzymes