Ephrin-A5 Products

Description

Ephrin A5, a member of the ephrin family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

Bioinformatics

Entrez	116683 Rat 13640 Mouse 1946 Human
Uniprot	NM_001962 Human NP_001953 Human P52803 Human
Product By Gene ID	1946
Alternate Names	AF1 AL-1 EPH-related receptor tyrosine kinase ligand 7 ephrin-A5 EPLG7 GLC1M LERK-7 LERK7EFL5 RAGS

Research Areas for Ephrin-A5

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Neuroscience
Vision