Recombinant Mouse EphA7 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

EphA7, also known as Mdk1, Hek11, Ehk3, Ebk, and Cek11, is a 115-120 kDa glycosylated member of the Eph family of transmembrane receptor tyrosine kinases (1, 2). The A and B classes of Eph proteins are distinguished by Ephrin ligand binding preference but have a common structural organization. EphA7 preferentially binds to and is activated by Ephrin-A1, -A2, -A3, -A4, and -A5 (3 - 6). Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. The 527 amino acid (aa) extracellular domain (ECD) of mouse EphA7 contains an N‑terminal Ephrin binding region, a cysteine-rich region, and two fibronectin type III domains (FnIII). The 421 aa cytoplasmic domain contains the tyrosine kinase domain and a sterile alpha motif (SAM) (7). Within the ECD, mouse EphA7 shares 98% and 99% aa sequence identity with human and rat EphA7, respectively. Alternate splicing generates a differentially expressed kinase-defective isoform of mouse EphA7 that lack most of the cytoplasmic domain and a soluble isoform that is truncated following the first FnIII domain (4, 6 - 9). In mouse, EphA7 is expressed in discrete regions of the developing and adult neocortex (4, 7 - 10), Purkinje layer of the cerebellum (7), limbic system (4, 8 ‑ 10), visual and auditory systems (7, 8, 11), and the peripheral sensory nervous system (7, 8). EphA7 functions as a repulsive guidance molecule during the targeting of retinal axons to the superior colliculus  and of neocortical axons to the thalamus (4, 10, 11). EphA7 is also expressed in mesenchymal cells along routes of axon innervation during limb development (12). EphA7 ligands are expressed in a complementary pattern during embryogenesis (3, 10 - 12). EphA7 is selectively expressed in early stages of the B cell lineage, and a 50 kDa secreted form is produced by mature peripheral B and T cells (6, 13). This isoform is also expressed in human lung carcinoma (14). EphA7 can be up or downregulated in a variety of human cancers (6, 15, 16).

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Chicken.

We have publications tested in 7 applications: Binding Assay, Bioassay, ICC, IHC, IHC-Fr, In Vivo, Western Blot Control.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using 608-A7	Applications	Species
LL Arnold, A Cecchini, DA Stark, J Ihnat, RN Craigg, A Carter, S Zino, D Cornelison EphA7 promotes myogenic differentiation via cell-cell contact Elife, 2020-04-21;9(0):. 2020-04-21 [PMID: 32314958] (Bioassay, Mouse)	Bioassay	Mouse
S Li, J Zhai, J Liu, F Di, Y Sun, W Li, ZJ Chen, Y Du Erythropoietin-producing hepatocellular A7 triggering ovulation indicates a potential beneficial role for polycystic ovary syndrome EBioMedicine, 2018-10-03;0(0):. 2018-10-03 [PMID: 30292674] (In Vivo, Mouse)	In Vivo	Mouse
Weiss A, Airik R, Bohnenpoll T, Greulich F, Foik A, Trowe M, Rudat C, Costantini F, Adams R, Kispert A Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme. Development, 2014-09-01;141(17):3420-30. 2014-09-01 [PMID: 25139858] (Bioassay, Mouse)	Bioassay	Mouse
Defourny J, Poirrier A, Lallemend F, Mateo Sanchez S, Neef J, Vanderhaeghen P, Soriano E, Peuckert C, Kullander K, Fritzsch B, Nguyen L, Moonen G, Moser T, Malgrange B Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells. Nat Commun, 2013-01-01;4(0):1438. 2013-01-01 [PMID: 23385583] (Bioassay, Mouse)	Bioassay	Mouse
EphA7 Expression Identifies a Unique Neuronal Compartment in the Rat Striatum [PMID: 23348681] (Western Blot Control, Mouse)	Western Blot Control	Mouse
Park , E, Kim , Y, Noh , H, Lee , H, Yoo , S, Park , S EphA/ephrin-A signaling is critically involved in region-specific apoptosis during early brain development. Cell Death Differ, 2012-09-14;20(1):169-80. 2012-09-14 [PMID: 22976838] (Bioassay, Mouse)	Bioassay	Mouse
Dewannieux M, Vernochet C, Ribet D, Bartosch B, Cosset FL, Heidmann T The mouse IAPE endogenous retrovirus can infect cells through any of the five GPI-anchored Ephrin A proteins. PLoS Pathog., 2011-10-20;7(10):e1002309. 2011-10-20 [PMID: 22028653] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Marler KJ, Poopalasundaram S, Broom ER Pro-neurotrophins secreted from retinal ganglion cell axons are necessary for ephrinA-p75NTR-mediated axon guidance. Neural Dev, 2010-11-02;5(0):30. 2010-11-02 [PMID: 21044296] (Bioassay, Chicken)	Bioassay	Chicken
Genander M, Holmberg J, Frisen J Ephrins negatively regulate cell proliferation in the epidermis and hair follicle. Stem Cells, 2010-07-01;28(7):1196-205. 2010-07-01 [PMID: 20506314] (IHC-Fr, In Vivo, Mouse)	IHC-Fr, In Vivo	Mouse
Afshari FT, Kwok JC, Fawcett JW Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling. J. Neurosci., 2010-03-24;30(12):4246-55. 2010-03-24 [PMID: 20335460] (Bioassay, Rat)	Bioassay	Rat
Torii M, Hashimoto-Torii K, Levitt P, Rakic P Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature, 2009-09-16;461(7263):524-8. 2009-09-16 [PMID: 19759535] (IHC, Mouse)	IHC	Mouse
Lim YS, McLaughlin T, Sung TC, Santiago A, Lee KF, O'Leary DD p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping. Neuron, 2008-09-11;59(5):746-58. 2008-09-11 [PMID: 18786358] (Bioassay, IHC-Fr, Mouse)	Bioassay, IHC-Fr	Mouse
Konstantinova I, Nikolova G, Ohara-Imaizumi M, Meda P, Kucera T, Zarbalis K, Wurst W, Nagamatsu S, Lammert E EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell, 2007-04-20;129(2):359-70. 2007-04-20 [PMID: 17448994] (Bioassay, Mouse)	Bioassay	Mouse
Chaudhari A, Mahfouz M, Fialho AM, Yamada T, Granja AT, Zhu Y, Hashimoto W, Schlarb-Ridley B, Cho W, Das Gupta TK, Chakrabarty AM Cupredoxin-cancer interrelationship: azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth. Biochemistry, 2007-01-24;46(7):1799-810. 2007-01-24 [PMID: 17249693] (Binding Assay, Human)	Binding Assay	Human
Rashid T, Upton AL, Blentic A, Ciossek T, Knoll B, Thompson ID, Drescher U Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system. Neuron, 2005-07-07;47(1):57-69. 2005-07-07 [PMID: 15996548] (Bioassay, IHC, Chicken, Mouse)	Bioassay, IHC	Chicken, Mouse
Munoz LM, Zayachkivsky A, Kunz RB, Hunt JM, Wang G, Scott SA Ephrin-A5 inhibits growth of embryonic sensory neurons. Dev. Biol., 2005-07-15;283(2):397-408. 2005-07-15 [PMID: 15949793] (ICC, Chicken)	ICC	Chicken
Murai KK, Nguyen LN, Koolpe M, McLennan R, Krull CE, Pasquale EB Targeting the EphA4 receptor in the nervous system with biologically active peptides. Mol. Cell. Neurosci., 2003-12-01;24(4):1000-11. 2003-12-01 [PMID: 14697664] (Binding Assay, Bioassay, Mouse)	Binding Assay, Bioassay	Mouse
Show All 17 Publications. Collapse Publications.

Array 608-A7

• EphA7 Antibodies
• EphA7 Proteins and Enzymes