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Recombinant Mouse CXCL10/IP-10/CRG-2 Protein

 (17 Publications)
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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Bioactivity

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Catalog# & Formulation Size Price
Standard Formulation
466-CR-050/CF
Carrier Free
466-CR-050/CF
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Recombinant Mouse CXCL10/IP-10/CRG-2 Protein Summary

Details of Functionality
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR3. The ED50 for this effect is 0.05-0.3 µg/mL.
Source
E. coli-derived mouse CXCL10/IP-10/CRG-2 protein
Ile22-Pro98, with an N-terminal Met
Accession #
N-terminal Sequence
Met
Protein/Peptide Type
Recombinant Proteins
Gene
Cxcl10
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity2
Theoretical MW
8.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
466-CR in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse CXCL10/IP-10/CRG-2 Protein

  • C7
  • chemokine (C-X-C motif) ligand 10
  • CRG2
  • CRG-2
  • CXCL10
  • gIP-10
  • IFI10
  • INP10
  • IP-10
  • mob-1
  • SCYB10

Background

The gene for CRG-2, a mouse homolog of human IP-10, was originally identified as an immediate early gene induced in response to macrophage activation. It has since been shown that CRG-2 mRNA is induced by alpha / beta / gamma -interferons and by lipopolysaccharide in macrophages, astrocytes and microglia. Human IP-10 was also shown to be expressed in activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. Mouse CRG-2 cDNA encodes a 98 amino acid (aa) residue precursor protein with a 21 aa residue signal peptide that is cleaved to form the 77 aa residue secreted mature protein. Mature CRG-2 shares approximately 67% amino acid sequence identity with human IP-10. The amino acid sequence of CRG-2 identified the protein as a member of the chemokine alpha subfamily that lacks the ELR domain. CRG-2 has been shown to be a chemoattractant for activated T-lymphocytes. Recently, human IP-10 has also been reported to be a potent inhibitor of angiogenesis and to display a potent thymus-dependent anti-tumor effect. A chemokine receptor specific for IP-10 and MIG (CXCR3) has been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes.

  1. Loetscher, M. et al. (1996) J. Exp. Med. 184:963.
  2. Vanguri, P. (1996) J. Neuroimmunol. 56:35.
  3. Sgadari, C. et al. (1996) Blood, 87:3877.

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Publications for CXCL10/IP-10/CRG-2 (466-CR)(17)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Binding Assay, Bioassay, ELISA (Standard), In Vivo.


Filter By Application
Binding Assay
(1)
Bioassay
(12)
ELISA (Standard)
(2)
In Vivo
(2)
All Applications
Filter By Species
Human
(1)
Mouse
(17)
All Species
Showing Publications 1 - 10 of 17. Show All 17 Publications.
Publications using 466-CR Applications Species
M Hashimoto, K Araki, MA Cardenas, P Li, RR Jadhav, HT Kissick, WH Hudson, DJ McGuire, RC Obeng, A Wieland, J Lee, DT McManus, JL Ross, SJ Im, J Lee, JX Lin, B Hu, EE West, CD Scharer, GJ Freeman, AH Sharpe, SS Ramalingam, A Pellerin, V Teichgräbe, WJ Greenleaf, C Klein, JJ Goronzy, P Umaña, WJ Leonard, KA Smith, R Ahmed PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program Nature, 2022-09-28;610(7930):173-181. 2022-09-28 [PMID: 36171288] (Bioassay, Mouse) Bioassay Mouse
JA Carroll, BR Groveman, K Williams, R Moore, B Race, CL Haigh Prion protein N1 cleavage peptides stimulate microglial interaction with surrounding cells Sci Rep, 2020-04-20;10(1):6654. 2020-04-20 [PMID: 32313035] (Bioassay, Mouse) Bioassay Mouse
YP Xu, L Lv, Y Liu, MD Smith, WC Li, XM Tan, M Cheng, Z Li, M Bovino, J Aubé, Y Xiong Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy J. Clin. Invest., 2019-07-16;130(0):. 2019-07-16 [PMID: 31310587] (Bioassay, Mouse) Bioassay Mouse
S Sharif, N Ueda, Y Nakatani, LM Wise, S Clifton, Z Lateef, AA Mercer, SB Fleming Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity Front Microbiol, 2019-06-25;10(0):1421. 2019-06-25 [PMID: 31293551] (Binding Assay, Mouse) Binding Assay Mouse
Q Zhao, T Kim, J Pang, W Sun, X Yang, J Wang, Y Song, H Zhang, H Sun, V Rangan, S Deshpande, H Tang, ME Cvijic, R Westhouse, T Olah, J Xie, M Struthers, L Salter-Cid A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines J. Leukoc. Biol., 2017-09-12;0(0):. 2017-09-12 [PMID: 28899907] (In Vivo, Mouse) In Vivo Mouse
S Geng, Y Zhong, X Zhou, G Zhao, X Xie, Y Pei, H Liu, H Zhang, Y Shi, B Wang Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Dependent Egress Blockage Front Immunol, 2017-06-07;8(0):663. 2017-06-07 [PMID: 28638384] (Bioassay, Mouse) Bioassay Mouse
EM Putz, AJ Mayfosh, K Kos, DS Barkauskas, K Nakamura, L Town, KJ Goodall, DY Yee, IK Poon, N Baschuk, F Souza-Fons, MD Hulett, MJ Smyth NK cell heparanase controls tumor invasion and immune surveillance J. Clin. Invest., 2017-06-05;0(0):. 2017-06-05 [PMID: 28581441] (Bioassay, Mouse) Bioassay Mouse
GM Castillo, A Nishimoto-, CC Jones, KK Kabirov, A Zakharov, AV Lyubimov Protected graft copolymer-formulated fibroblast growth factors mitigate the lethality of partial body irradiation injury PLoS ONE, 2017-02-16;12(2):e0171703. 2017-02-16 [PMID: 28207794] (ELISA (Standard), Mouse) ELISA (Standard) Mouse
Ioannidis L, Nie C, Ly A, Ryg-Cornejo V, Chiu C, Hansen D Monocyte- and Neutrophil-Derived CXCL10 Impairs Efficient Control of Blood-Stage Malaria Infection and Promotes Severe Disease. J Immunol, 2015-12-30;196(3):1227-38. 2015-12-30 [PMID: 26718341] (ELISA (Standard), Mouse) ELISA (Standard) Mouse
Mitagami Y, Yasunaga J, Kinosada H, Ohshima K, Matsuoka M Interferon-gamma Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice. PLoS Pathog, 2015-08-21;11(8):e1005120. 2015-08-21 [PMID: 26296091] (Bioassay, Mouse) Bioassay Mouse
Show All 17 Publications.

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Bioinformatics

Gene Symbol Cxcl10
Uniprot