Recombinant Mouse 4-1BB/TNFRSF9 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

4-1BB, also known as CD137 and TNFRSF9, is an approximately 30 kDa transmembrane glycoprotein in the TNF receptor superfamily. 4-1BB functions in the development and activation of multiple immune cells (1). Mature mouse 4-1BB consists of a 164 amino acid (aa) extracellular domain (ECD) with four TNFR cysteine‑rich repeats, a 21 aa transmembrane segment, and a 48 aa cytoplasmic domain (2). Within the ECD, mouse 4-1BB shares 60% and 79% aa sequence identity with human and rat 4-1BB, respectively. 4-1BB is expressed as a disulfide-linked homodimer on various populations of activated T cells including CD4⁺, CD8⁺, memory CD8⁺, NKT, and regulatory T cells (3-6) as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts (7-10). It binds with high affinity to the transmembrane 4-1BB Ligand/TNFSF9 which is expressed on antigen presenting cells and myeloid progenitor cells (7, 11). This interaction co‑stimulates the proliferation, activation, and/or survival of the 4-1BB expressing cell (3-6, 11). It can also enhance the activation-induced cell death of repetitively stimulated T cells (11). Mice lacking 4-1BB show augmented T cell activation, perhaps due to its absence on regulatory T cells (12). 4-1BB can associate with OX40 on activated T cells, forming a complex that responds to either ligand and inhibits Treg and CD8⁺ T cell proliferation (13). Reverse signaling through 4-1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts (7, 10) but supports mature dendritic cell survival and co‑stimulates the proliferation and activation of mast cells (8, 9). 4‑1BB activation enhances CD8⁺ T cell and NK cell mediated anti-tumor immunity (14). It also contributes to the development of inflammation in high fat diet-induced metabolic syndrome (15). Soluble forms of 4-1BB and 4-1BB Ligand circulate at elevated levels in the serum of rheumatoid arthritis and hematologic cancer patients, respectively (16, 17).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, ELISA (Capture).

Showing Publications 1 - 3 of 3.

Publications using 937-4B	Applications	Species
KM Au, SI Park, AZ Wang Trispecific natural killer cell nanoengagers for targeted chemoimmunotherapy Sci Adv, 2020-07-03;6(27):eaba8564. 2020-07-03 [PMID: 32923587] (Bioassay, Mouse)	Bioassay	Mouse
M Compte, SL Harwood, IG Muñoz, R Navarro, M Zonca, G Perez-Chac, A Erce-Llama, N Merino, A Tapia-Gali, AM Cuesta, K Mikkelsen, E Caleiras, N Nuñez-Prad, MA Aznar, S Lykkemark, J Martínez-T, I Melero, FJ Blanco, J Bernardino, JM Zapata, L Sanz, L Alvarez-Va A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity Nat Commun, 2018-11-15;9(1):4809. 2018-11-15 [PMID: 30442944] (ELISA (Capture), Mouse)	ELISA (Capture)	Mouse
Kang YJ, Kim SO, Shimada S, Otsuka M, Seit-Nebi A, Kwon BS, Watts TH, Han J Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages. Nat. Immunol., 2007-05-13;8(6):601-9. 2007-05-13 [PMID: 17496895] (Bioassay, Mouse)	Bioassay	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	Binding assay/Protein-protein interaction		12/16/2018	View Summary Application Binding assay/Protein-protein interaction Lot EJT0318041

Array 937-4B

• 4-1BB/TNFRSF9/CD137 Antibodies
• 4-1BB/TNFRSF9/CD137 ELISA Kit
• 4-1BB/TNFRSF9/CD137 Proteins
• 4-1BB/TNFRSF9/CD137 ELISAs
• 4-1BB/TNFRSF9/CD137 Proteins and Enzymes