Recombinant Human VEGF-C Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Vascular endothelial growth factor C (VEGF-C) and VEGF-D constitute a subfamily of the angiogenic VEGF angiogenic factors (1). VEGF-C is synthesized as a 58 kDa molecule that consists of a VEGF homolgy domain (VHD) flanked by N- and C-terminal propeptides. The proprotein undergoes covalent homodimerization and stepwise proteolytic processing to generate ligands with increasing affinity for VEGF R3/Flt-4 (2-4). Fully processed VEGF-C containing just the 21 kDa VHD can additionally bind and activate VEGF R2/KDR/Flk-1 (2, 4). Fully processed human VEGF-C shares 98% amino acid sequence identity with mouse and rat VEGF-C. VEGF-C interactions with VEGF R3 are critical for lymphangiogenesis (5-8). VEGF-C and VEGF R3 are usually co-expressed at sites with lymphatic vessel sprouting, in the embryo, and in various pathological conditions. Over-expression of VEGF-C in tumor cells induces tumoral lymphatic hyperplasia, resulting in enhanced lymph flow and metastasis to regional lymph nodes (9-12). It also induces physiological and intratumoral neoangiogenesis and vessel sprouting through interactions with VEGF R2 (8, 13, 14).

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: Bioassay, In Vivo.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using 9199-VC	Applications	Species
Chen, D;Wiggins, D;Sevick, EM;Davis, MJ;King, PD; An EPHB4-RASA1 signaling complex inhibits shear stress-induced Ras-MAPK activation in lymphatic endothelial cells to promote the development of lymphatic vessel valves bioRxiv : the preprint server for biology 2023-11-23 [PMID: 38045382] (Bioassay, Human)	Bioassay	Human
Lee, E;Chan, SL;Lee, Y;Polacheck, WJ;Kwak, S;Wen, A;Nguyen, DT;Kutys, ML;Alimperti, S;Kolarzyk, AM;Kwak, TJ;Eyckmans, J;Bielenberg, DR;Chen, H;Chen, CS; A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex Proceedings of the National Academy of Sciences of the United States of America 2023-10-10 [PMID: 37782785] (Bioassay, Human)	Bioassay	Human
K C, R;Patel, NR;Shenoy, A;Scallan, JP;Chiang, MY;Galazo, MJ;Meadows, SM; Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function bioRxiv : the preprint server for biology 2023-07-22 [PMID: 37503058] (Bioassay, Human)	Bioassay	Human
Farahani, PE;Yang, X;Mesev, EV;Fomby, KA;Brumbaugh-Reed, EH;Bashor, CJ;Nelson, CM;Toettcher, JE; pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells eLife 2023-05-22 [PMID: 37212240] (Bioassay, Mouse)	Bioassay	Mouse
R Islam, J Mishra, NS Polavaram, S Bhattachar, Z Hong, S Bodas, S Sharma, A Bouska, T Gilbreath, AM Said, LM Smith, BA Teply, MH Muders, SK Batra, K Datta, S Dutta Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance Oncogene, 2022-07-19;40(3):111097. 2022-07-19 [PMID: 35858551] (Bioassay, Human)	Bioassay	Human
F Morfoisse, F De Toni, J Nigri, M Hosseini, A Zamora, F Tatin, F Pujol, JE Sarry, D Langin, E Lacazette, AC Prats, R Tomasini, J Galitzky, A Bouloumié, B Garmy-Susi Coordinating Effect of VEGFC and Oleic Acid Participates to Tumor Lymphangiogenesis Cancers, 2021-06-08;13(12):. 2021-06-08 [PMID: 34200994] (Bioassay, Human)	Bioassay	Human
X Geng, K Yanagida, RG Akwii, D Choi, L Chen, Y Ho, B Cha, MR Mahamud, K Berman de, H Ichise, H Chen, J Wythe, CM Mikelis, T Hla, RS Srinivasan S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling JCI Insight, 2020-07-23;0(0):. 2020-07-23 [PMID: 32544090] (Bioassay, Human)	Bioassay	Human
TW Chung, EY Kim, HJ Choi, CW Han, SB Jang, KJ Kim, L Jin, YJ Koh, KT Ha 6'-Sialylgalactose inhibits vascular endothelial growth factor receptor 2-mediated angiogenesis Exp. Mol. Med., 2019-10-11;51(10):120. 2019-10-11 [PMID: 31604908] (Bioassay, Human)	Bioassay	Human
R Lopez-Bell, S Puig, PJ Huang, CR Tsai, HN Turner, MJ Galko, HB Gutstein Growth factor signaling regulates mechanical nociception in flies and vertebrates J. Neurosci., 2019-05-28;0(0):. 2019-05-28 [PMID: 31138657] (Bioassay, In Vivo, Rat)	Bioassay, In Vivo	Rat
M Frye, A Taddei, C Dierkes, I Martinez-C, M Fielden, H Ortsäter, J Kazenwadel, DP Calado, P Ostergaard, M Salminen, L He, NL Harvey, F Kiefer, T Mäkinen Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program Nat Commun, 2018-04-17;9(1):1511. 2018-04-17 [PMID: 29666442] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
YC Lin, N Ohbayashi, T Hongu, N Katagiri, Y Funakoshi, H Lee, Y Kanaho Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration Sci Rep, 2017-09-12;7(1):11431. 2017-09-12 [PMID: 28900118] (Bioassay, Human)	Bioassay	Human
KT Campbell, DJ Hadley, DL Kukis, EA Silva Alginate hydrogels allow for bioactive and sustained release of VEGF-C and VEGF-D for lymphangiogenic therapeutic applications PLoS ONE, 2017-07-19;12(7):e0181484. 2017-07-19 [PMID: 28723974]
S Yu, H Lv, H Zhang, Y Jiang, Y Hong, R Xia, Q Zhang, W Ju, L Jiang, G Ou, J Zhang, S Wang, J Zhang Heparanase-1-induced shedding of heparan sulfate from syndecan-1 in hepatocarcinoma cell facilitates lymphatic endothelial cell proliferation via VEGF-C/ERK pathway Biochem. Biophys. Res. Commun, 2017-02-13;0(0):. 2017-02-13 [PMID: 28209511] (Bioassay, Mouse)	Bioassay	Mouse
Show All 13 Publications. Collapse Publications.

Array 9199-VC

• VEGF-C Antibodies
• VEGF-C ELISA Kits
• VEGF-C Lysate
• VEGF-C ELISAs
• VEGF-C Proteins and Enzymes