Recombinant Human VEGF-C (Cys156Ser) Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Vascular endothelial growth factor C (VEGF-C) and VEGF-D constitute a subfamily of the angiogenic VEGF angiogenic factors (1). VEGF-C is synthesized as a 58 kDa molecule that consists of a VEGF homolgy domain (VHD) flanked by N- and C-terminal propeptides. The proprotein undergoes covalent homodimerization and stepwise proteolytic processing to generate ligands with increasing affinity for VEGF R3/Flt-4 (2-4). Fully processed VEGF-C containing just the 21 kDa VHD can additionally bind and activate VEGF R2/KDR/Flk-1 (2, 4). Fully processed human VEGF-C shares 98% amino acid sequence identity with mouse and rat VEGF-C. VEGF-C interactions with VEGF R3 are critical for lymphangiogenesis (5-8). VEGF-C and VEGF R3 are usually co-expressed at sites with lymphatic vessel sprouting, in the embryo, and in various pathological conditions. Over-expression of VEGF-C in tumor cells induces tumoral lymphatic hyperplasia, resulting in enhanced lymph flow and metastasis to regional lymph nodes (9-12). It also induces physiological and intratumoral neoangiogenesis and vessel sprouting through interactions with VEGF R2 (8, 13, 14).

We have publications tested in 4 confirmed species: Human, Mouse, Transgenic Mouse, Xenopus.

We have publications tested in 4 applications: Bioassay, Cell Culture, In Vivo, In vivo assay.

Showing Publications 1 - 10 of 23. Show All 23 Publications. Collapse Publications.

Publications using 752-VC	Applications	Species
Chen, YL;Lin, YN;Xu, J;Qiu, YX;Wu, YH;Qian, XG;Wu, YQ;Wang, ZN;Zhang, WW;Li, YC; Macrophage-derived VEGF-C reduces cardiac inflammation and prevents heart dysfunction in CVB3-induced viral myocarditis via remodeling cardiac lymphatic vessels International immunopharmacology 2024-10-14 [PMID: 39405931] (In vivo assay, Mouse)	In vivo assay	Mouse
Liu, Z;Liu, K;Shi, S;Chen, X;Gu, X;Wang, W;Mao, K;Yibulayi, R;Wu, W;Zeng, L;Zhou, W;Lin, X;Zhang, F;Lou, B; Alkali injury-induced pathological lymphangiogenesis in the iris facilitates the infiltration of T cells and ocular inflammation JCI insight 2024-04-08 [PMID: 38587075] (In vivo assay, Mouse, Transgenic Mouse)	In vivo assay	Mouse, Transgenic Mouse
Wang, YJ;Zheng, Y;Cong, L;Wang, P;Zhao, L;Xing, L;Liu, J;Xu, H;Li, N;Zhao, Y;Shi, Q;Liang, Q; Lymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs Research square 2023-11-14 [PMID: 38014223] (In Vivo, Mouse)	In Vivo	Mouse
Choi, YH;Hsu, M;Laaker, C;Herbath, M;Yang, H;Cismaru, P;Johnson, AM;Spellman, B;Wigand, K;Sandor, M;Fabry, Z; Dual role of Vascular Endothelial Growth Factor-C (VEGF-C) in post-stroke recovery bioRxiv : the preprint server for biology 2023-09-01 [PMID: 37693558] (In Vivo, Mouse)	In Vivo	Mouse
Babaei, Z;Panjehpour, M;Parsian, H;Aghaei, M; SAR131675 exhibits anticancer activity on human ovarian cancer cells through inhibition of VEGFR-3/ERK1/2/AKT signaling pathway Cellular signalling 2023-08-19 [PMID: 37598918] (Bioassay, Human)	Bioassay	Human
S Dutta, NS Polavaram, R Islam, S Bhattachar, S Bodas, T Mayr, S Roy, SAY Albala, MI Toma, A Darehshour, A Borkowetz, S Conrad, S Fuessel, M Wirth, GB Baretton, LC Hofbauer, P Ghosh, KJ Pienta, DL Klinkebiel, SK Batra, MH Muders, K Datta Neuropilin-2 regulates androgen-receptor transcriptional activity in advanced prostate cancer Oncogene, 2022-06-27;0(0):. 2022-06-27 [PMID: 35754042] (Bioassay, Human)	Bioassay	Human
A Chakrabort, R Upadhya, TA Usman, AK Shetty, JM Rutkowski Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress Brain, Behavior, and Immunity, 2021-08-11;0(0):. 2021-08-11 [PMID: 34389489] (Bioassay, Human)	Bioassay	Human
Y Shimizu, R Polavarapu, KL Eskla, Y Pantner, CK Nicholson, M Ishii, D Brunnhoelz, R Mauria, A Husain, N Naqvi, T Murohara, JW Calvert Impact of Lymphangiogenesis on Cardiac Remodeling After Ischemia and Reperfusion Injury J Am Heart Assoc, 2018-10-02;7(19):e009565. 2018-10-02 [PMID: 30371303] (Bioassay, Human)	Bioassay	Human
JM Vieira, S Norman, C Villa Del, TJ Cahill, DN Barnette, M Gunadasa-R, LA Johnson, DR Greaves, CA Carr, DG Jackson, PR Riley The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction J. Clin. Invest., 2018-07-09;0(0):. 2018-07-09 [PMID: 29985167] (In Vivo, Mouse)	In Vivo	Mouse
YR Wen, JH Yang, X Wang, ZB Yao Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease Neural Regen Res, 2018-04-01;13(4):709-716. 2018-04-01 [PMID: 29722325] (Bioassay, In Vivo, Human, Mouse)	Bioassay, In Vivo	Human, Mouse
K Rauniyar, SK Jha, M Jeltsch Biology of Vascular Endothelial Growth Factor C in the Morphogenesis of Lymphatic Vessels Front Bioeng Biotechnol, 2018-02-12;6(0):7. 2018-02-12 [PMID: 29484295] (Cell Culture, Human)	Cell Culture	Human
Louveau A, Smirnov I, Keyes T, Eccles J, Rouhani S, Peske J, Derecki N, Castle D, Mandell J, Lee K, Harris T, Kipnis J Structural and functional features of central nervous system lymphatic vessels. Nature, 2015-06-01;523(7560):337-41. 2015-06-01 [PMID: 26030524] (In Vivo, Mouse)	In Vivo	Mouse
Heishi T, Hosaka T, Suzuki Y, Miyashita H, Oike Y, Takahashi T, Nakamura T, Arioka S, Mitsuda Y, Takakura T, Hojo K, Matsumoto M, Yamauchi C, Ohta H, Sonoda H, Sato Y Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis. Am. J. Pathol., 2010-02-04;176(4):1950-8. 2010-02-04 [PMID: 20133819] (In Vivo, Mouse)	In Vivo	Mouse
Chien MH, Ku CC, Johansson G, Chen MW, Hsiao M, Su JL, Inoue H, Hua KT, Wei LH, Kuo ML Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. Carcinogenesis, 2009-12-01;30(12):2005-13. 2009-12-01 [PMID: 19825968] (Bioassay, Human)	Bioassay	Human
Kajiya K, Sawane M, Huggenberger R, Detmar M Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis. J. Invest. Dermatol., 2008-11-13;129(5):1292-8. 2008-11-13 [PMID: 19005491] (In Vivo, Mouse)	In Vivo	Mouse
Shin JW, Huggenberger R, Detmar M Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis. Blood, 2008-07-09;112(6):2318-26. 2008-07-09 [PMID: 18614759] (Bioassay, Human)	Bioassay	Human
Uzarski J, Drelles MB, Gibbs SE, Ongstad EL, Goral JC, McKeown KK, Raehl AM, Roberts MA, Pytowski B, Smith MR, Goldman J The resolution of lymphedema by interstitial flow in the mouse tail skin. Am. J. Physiol. Heart Circ. Physiol., 2008-01-18;294(3):H1326-34. 2008-01-18 [PMID: 18203849] (In Vivo, Mouse)	In Vivo	Mouse
Kilic N, Oliveira-Ferrer L, Neshat-Vahid S, Irmak S, Obst-Pernberg K, Wurmbach JH, Loges S, Kilic E, Weil J, Lauke H, Tilki D, Singer BB, Ergun S Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1. Blood, 2007-08-30;110(13):4223-33. 2007-08-30 [PMID: 17761831] (Bioassay, Human)	Bioassay	Human
Huber S, Bruns CJ, Schmid G, Hermann PC, Conrad C, Niess H, Huss R, Graeb C, Jauch KW, Heeschen C, Guba M Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis. Kidney Int., 2007-02-14;71(8):771-7. 2007-02-14 [PMID: 17299523] (Bioassay, Human)	Bioassay	Human
Goldman J, Conley KA, Raehl A, Bondy DM, Pytowski B, Swartz MA, Rutkowski JM, Jaroch DB, Ongstad EL Regulation of lymphatic capillary regeneration by interstitial flow in skin. Am. J. Physiol. Heart Circ. Physiol., 2006-12-22;292(5):H2176-83. 2006-12-22 [PMID: 17189348] (In Vivo, Mouse)	In Vivo	Mouse
Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Breant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat. Neurosci., 2006-02-05;9(3):340-8. 2006-02-05 [PMID: 16462734] (Bioassay, Mouse, Xenopus)	Bioassay	Mouse, Xenopus
Shin JW, Min M, Larrieu-Lahargue F, Canron X, Kunstfeld R, Nguyen L, Henderson JE, Bikfalvi A, Detmar M, Hong YK Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol. Biol. Cell, 2005-11-16;17(2):576-84. 2005-11-16 [PMID: 16291864] (Bioassay, Human)	Bioassay	Human
Hamaguchi I, Morisada T, Azuma M, Murakami K, Kuramitsu M, Mizukami T, Ohbo K, Yamaguchi K, Oike Y, Dumont DJ, Suda T Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival. Blood, 2005-10-11;107(3):1207-13. 2005-10-11 [PMID: 16219799] (Bioassay, Mouse)	Bioassay	Mouse
Show All 23 Publications. Collapse Publications.

Array 752-VC

• VEGF-C Antibodies
• VEGF-C ELISA Kits
• VEGF-C Lysate
• VEGF-C ELISAs
• VEGF-C Proteins and Enzymes